Association of urinary creatinine excretion and body mass index with diabetic retinopathy in patients with type 2 diabetes

被引:0
作者
Chung, Jin Ook [1 ]
Park, Seon-Young [2 ]
Kim, Bitz-na [1 ]
Cho, Dong Hyeok [1 ]
Chung, Dong Jin [1 ]
Chung, Min Young [1 ]
机构
[1] Chonnam Natl Univ, Dept Internal Med, Div Endocrinol & Metab, Med Sch, 8 Hak Dong, Gwangju 501757, South Korea
[2] Chonnam Natl Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Med Sch, 8 Hak Dong, Gwangju 501757, South Korea
基金
新加坡国家研究基金会;
关键词
Body mass index; Creatinine; Diabetic retinopathy; Muscle; SKELETAL-MUSCLE; INSULIN-RESISTANCE; NATIONAL-HEALTH; MORTALITY; RISK; PREVALENCE; DIAGNOSIS; DISEASE; OBESITY; HUMANS;
D O I
10.1038/s41598-024-68220-1
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
This study aimed to determine whether urinary creatinine excretion rate (CER), a marker of muscle mass, is associated with diabetic retinopathy in individuals with type 2 diabetes and to ascertain whether this putative association depends on body mass index (BMI). This cross sectional study evaluated 2035 individuals with type 2 diabetes. Twenty-four-hour urine was collected. Individuals with diabetic retinopathy had lower CER and BMI values than those without. Patients in higher CER quartiles had higher BMI values and a lower prevalence of diabetic retinopathy. A significant relationship between CER and diabetic retinopathy persisted, even after adjusting for traditional risk factors, including glycated hemoglobin, diabetes duration, and hypertension, in multivariable analysis. Further adjustment for BMI did not significantly alter the association between CER and diabetic retinopathy. This study suggests that CER is inversely associated with diabetic retinopathy in individuals with type 2 diabetes, and this association is independent of BMI.
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页数:9
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