Incidence of Clostridioides difficile Infections in Republic of Korea: A Prospective Study With Active Surveillance vs. National Data From Health Insurance Review & Assessment Service

被引:5
作者
Kim, Jieun [1 ]
Myung, Rangmi [2 ]
Kim, Bongyoung [1 ]
Kim, Jinyeong [3 ]
Kim, Tark [4 ]
Lee, Mi Suk [5 ]
Kim, Uh Jin [6 ]
Park, Dae Won [7 ]
Kim, Yeon-Sook [8 ]
Lee, Chang-Seop [9 ,10 ]
Kim, Eu Suk [11 ]
Lee, Sun Hee [12 ]
Chang, Hyun-Ha [13 ]
Lee, Seung Soon [14 ]
Park, Se Yoon [1 ]
Choi, Hee Jung [15 ]
Kim, Hye In [16 ]
Ha, Young Eun [17 ]
Wi, Yu Mi [18 ]
Choi, Sungim [19 ]
Shin, So Youn [20 ]
Pai, Hyunjoo [1 ,21 ]
机构
[1] Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea
[2] Natl Hlth Insurance Serv, Dept Nonbenefits Management, Wonju, South Korea
[3] Hanyang Univ, Guri Hosp, Guri, South Korea
[4] Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Divison Infect Dis, Bucheon, South Korea
[5] Kyung Hee Univ, Coll Med, Dept Internal Med, Seoul, South Korea
[6] Chonnam Natl Univ, Dept Infect Dis, Med Sch, Gwangju, South Korea
[7] Korea Univ, Dept Internal Med, Div Infect Dis, Ansan Hosp, Ansan, South Korea
[8] Chungnam Natl Univ, Sch Med, Div Infect Dis, Daejeon, South Korea
[9] Jeonbuk Natl Univ, Med Sch & Hosp, Dept Internal Med, Jeonju, South Korea
[10] Jeonbuk Natl Univ, Med Sch Hosp, Res Inst Clin Med, Jeonju, South Korea
[11] Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Internal Med, Seongnam, South Korea
[12] Pusan Natl Univ, Sch Med, Dept Internal Med, Busan, South Korea
[13] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Infect Dis, Daegu, South Korea
[14] Hallym Univ, Coll Med, Chuncheon Sacred Heart Hosp, Dept Internal Med, Chunchon, South Korea
[15] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea
[16] Daegu Fatima Hosp, Dept Infect Dis, Daegu, South Korea
[17] Bucheon Sejong Hosp, Dept Infect Dis, Bucheon, South Korea
[18] Sungkyunkwan Univ, Samsung Changwon Hosp, Div Infect Dis, Chang Won, South Korea
[19] Dongguk Univ, Ilsan Hosp, Div Infect Dis, Goyang, South Korea
[20] Catholic Kwandong Univ, Coll Med, Int St Marys Hosp, Dept Infect Dis, Incheon, South Korea
[21] Hanyang Univ, Coll Med, Dept Internal Med, Div Infect Dis, 222 Wangsimni Ro, Seoul 04763, South Korea
关键词
Clostridioides difficile Infection; Incidence; Active Surveillance; Big Data; CLINICAL-FEATURES; EPIDEMIOLOGY; HOSPITALS;
D O I
10.3346/jkms.2024.39.e118
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Since the emergence of hypervirulent strains of Clostridioides difficile, the incidence of C. difficile infections (CDI) has increased significantly. Methods: To assess the incidence of CDI in Korea, we conducted a prospective multicentre observational study from October 2020 to October 2021. Additionally, we calculated the incidence of CDI from mass data obtained from the Health Insurance Review and Assessment Service (HIRA) from 2008 to 2020. Results: In the prospective study with active surveillance, 30,212 patients had diarrhoea and 907 patients were diagnosed with CDI over 1,288,571 patient -days and 193,264 admissions in 18 participating hospitals during 3 months of study period; the CDI per 10,000 patientdays was 7.04 and the CDI per 1,000 admission was 4.69. The incidence of CDI was higher in general hospitals than in tertiary hospitals: 6.38 per 10,000 patient -days (range: 3.25-12.05) and 4.18 per 1,000 admissions (range: 1.92-8.59) in 11 tertiary hospitals, vs. 9.45 per 10,000 patient -days (range: 5.68-13.90) and 6.73 per 1,000 admissions (range: 3.18-15.85) in seven general hospitals. With regard to HIRA data, the incidence of CDI in all hospitals has been increasing over the 13 -year -period: from 0.3 to 1.8 per 10,000 patient -days, 0.3 to 1.6 per 1,000 admissions, and 6.9 to 56.9 per 100,000 population, respectively. Conclusion: The incidence of CDI in Korea has been gradually increasing, and its recent value is as high as that in the United State and Europe. CDI is underestimated, particularly in general hospitals in Korea.
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页数:10
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