Association of HDL-Cholesterol, hypertension and left ventricular hypertrophy in youths with overweight or obesity

被引：3

作者：

Di Bonito, Procolo ^{[1
]}

Morandi, Anita ^{[2
,3
]}

Licenziati, Maria Rosaria ^{[4
]}

Di Sessa, Anna ^{[5
]}

Giudice, Emanuele Miraglia del ^{[5
]}

Faienza, Maria Felicia ^{[6
]}

Corica, Domenico ^{[7
]}

Wasniewska, Malgorzata ^{[7
]}

Mozzillo, Enza ^{[8
]}

Maltoni, Giulio ^{[9
]}

Franco, Francesca ^{[10
]}

Calcaterra, Valeria ^{[11
,12
]}

Moio, Nicola ^{[13
]}

Maffeis, Claudio ^{[2
,3
]}

Valerio, Giuliana ^{[14
]}

机构：

[1] Pozzuoli Hosp, Dept Internal Med, Naples, Italy

[2] Univ Verona, Sect Pediat Diabet & Metab, Dept Surg Dent Pediat & Gynecol, Verona, Italy

[3] Azienda Osped Univ Integrata Verona, Verona, Italy

[4] Santobono Pausilipon Childrens Hosp, Dept Neurosci, Neuroendocrine Dis & Obes Unit, Naples, Italy

[5] Univ Campania Luigi Vanvitelli, Dept Woman Child Gen & Specialized Surg, Naples, Italy

[6] Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian Area, Bari, Italy

[7] Univ Messina, Dept Human Pathol Adulthood & Childhood, Messina, Italy

[8] Univ Naples Federico II, Reg Ctr Pediat Diabet, Dept Translat Med Sci, Sect Pediat, Naples, Italy

[9] IRCCS Azienda Osped Univ Bologna, Pediat Unit, Bologna, Italy

[10] Azienda Sanit Univ Friuli Cent, Hosp Udine, Pediat Dept, Udine, Italy

[11] V Buzzi Childrens Hosp, Pediat Dept, Milan, Italy

[12] Univ Pavia, Dept Internal Med, Pavia, Italy

[13] Pozzuoli Hosp, Dept Cardiol, Naples, Italy

[14] Univ Napoli Parthenope, Dept Movement Sci & Wellbeing, Via Medina 40, I-80133 Naples, Italy

来源：

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2024年 / 34卷 / 02期

关键词：

Children; Hypertension; HDL-Cholesterol; Left ventricular hypertrophy; Obesity; ESTER TRANSFER PROTEIN; CORONARY-HEART-DISEASE; LIPOPROTEIN CHOLESTEROL; RISK-FACTORS; TORCETRAPIB; ATHEROSCLEROSIS; CHILDREN; WEIGHT; HEIGHT;

D O I：

10.1016/j.numecd.2023.09.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aim: To evaluate the relationship between HDL-Cholesterol (HDL-C), hypertension, and left ventricular hypertrophy (LVH) in a large sample of Caucasian youths with overweight/obesity (OW/OB). Methods and results: A cross-sectional multicenter study was performed in 1469 youths (age 6-16 years) with OW/OB observed in the period 2016-2020. An additional independent sample of 244 youths with an echocardiographic evaluation, observed in a single center was analyzed. The sample was divided in six quantiles (Q) of HDL-C: Q1: >56, Q2: <= 56 > 51, Q3: <= 51 > 45, Q4: <= 45 > 41, Q5: <= 41 > 39, Q6: <39 mg/dL. The nadir of the relationship was identified in youths in the first quantile. Among HDL-Cholesterol quantiles the distribution of hypertension was non-linear with a percentage of 25.0%, 40.1%, 33.6%, 31.3%, 35.2% and 39.7% in the six quantiles, respectively. The percentage of LVH was 21.8%, 43.6%, 48.8%, 35.5%, 38.5% and 52.0% in the six quantiles, respectively. The highest odds [95%Cl] of hypertension were 2.05 (1.33-3.16) (P < 0.01) in Q2, 1.67 (1.10-2.55) (P < 0.05) in Q3 and 1.59 (1.05-2.41) (P < 0.05) in Q6 vs Q1. The odds of LVH were 3.86 (1.15-10.24) (P < 0.05) in Q2, 4.16 (1.58-10.91) (P < 0.05) in Q3 and 3.60 (1.44-9.02) (P < 0.05) in Q6 vs Q1, independently by centers, age, sex, prepubertal stage, and body mass index. Conclusion: Contrary to the common belief, the present study shows that high levels of HDL-C may be not considered a negative predictor of hypertension and LVH, two risk factors for future CV disease.

引用

页码：299 / 306

页数：8

共 38 条

[31] HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial [J].