NUT midline carcinoma presenting initially as thyroid cancer: a case report and review of treatment

被引：1

作者：

Neumann, Melissa ^{[1
]}

Hines, Adam ^{[2
]}

Chang, Qing ^{[2
]}

Seetharamu, Nagashree ^{[2
]}

Lopez, Carlos A. ^{[2
]}

机构：

[1] Sch Med Hofstra Northwell, Donald & Barbara Zucker, 300 Community Dr, Manhasset, NY 11030 USA

[2] Northwell Hlth Canc Inst, Sch Med Hofstra Northwell, Donald & Barbara Zucker, Lake Success, NY 10021 USA

来源：

JOURNAL OF TRANSLATIONAL GENETICS AND GENOMICS | 2022年 / 6卷 / 03期

关键词：

Nuclear in Testis (NUT) carcinoma; NUT midline carcinoma; NUT midline carcinoma thyroid; NUT midline carcinoma BET; NUT midline carcinoma histone methyltransferase; NUT-midline immune checkpoint inhibitors; NUT midline treatment; DIFFERENTIATION; PATHOGENESIS; INHIBITORS; FEATURES; OUTCOMES; TARGET; HEAD;

D O I：

10.20517/jtgg.2022.06

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The purpose of this abstract is to provide data on a 27 -year -old woman with a rare and rapidly progressive cancer, Nuclear in Testis (NUT) carcinoma (NC), and to highlight possible treatment options for her specific gene translocation of NSD3-NUT. To our knowledge, this is the first case in the literature that was presented initially as anaplastic thyroid cancer. We propose that targeted therapy with a histone lysine methyltransferase inhibitor may be of benefit as adjunctive therapy in patients with the NSD3-NUT gene translocation.

引用

页码：353 / 360

页数：8

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