Risk Compensation After Initiation of Daily Oral Pre-exposure Prophylaxis Among Sexual and Gender Minorities in Nigeria

被引：0

作者：

Adeyemi, Olusegun A. ^{[1
,2
]}

Nowak, Rebecca G. ^{[3
]}

Morgan, Daniel ^{[1
]}

Sam-Agudu, Nadia A. ^{[2
,3
]}

Craddock, Jaih ^{[4
]}

Zhan, Min ^{[5
]}

Crowell, Trevor A. ^{[6
,7
]}

Baral, Stefan ^{[8
]}

Adebajo, Sylvia ^{[9
]}

Charurat, Manhattan E. ^{[3
]}

机构：

[1] Univ Maryland, Dept Publ Hlth & Epidemiol, Sch Med, 725 West Lombard St,S422, Baltimore, MD 21201 USA

[2] Inst Human Virol Nigeria, Int Res Ctr Excellence, Abuja, Nigeria

[3] Univ Maryland, Inst Human Virol, Sch Med, Baltimore, MD USA

[4] Univ Calif Irvine, Sch Med, Irvine, CA USA

[5] Univ Maryland, Dept Publ Hlth & Epidemiol, Div Biostat & Bioinformat, Sch Med, Baltimore, MD USA

[6] Henry M Jackson Fdn Advancement Mil Med, Bethesda, MD USA

[7] US Mil HIV Res Program, Silver Spring, MD USA

[8] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA

[9] Ctr Int Hlth Educ & Biosecur, Abuja, Nigeria

来源：

ARCHIVES OF SEXUAL BEHAVIOR | 2024年 / 53卷 / 07期

关键词：

Pre-exposure prophylaxis; Sexual and gender minority; Sexually transmitted infections; Risk adjustment behaviors; Sexual orientation; HIV; MEN; PREP; BEHAVIOR; ADHERENCE; MSM;

D O I：

10.1007/s10508-024-02859-9

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Pre-exposure prophylaxis (PrEP) use may be associated with risk compensation. We enrolled and provided PreP to sexual and gender minorities (SGM) in Abuja, Nigeria between April 2018 and May 2019. Behavioral information and samples for urogenital and anorectal Chlamydia trachomatis and Neisseria gonorrhoeae sexually transmitted infections (STIs) were collected at baseline. Blood samples for PrEP assay and self-reported adherence were collected at three-monthly follow-up visits. STIs were detected using Aptima Combo2 assay. We estimated the odds ratios (ORs) of PCR-diagnosed bacterial STIs and self-reported behavioral outcomes (condomless anal intercourse [CAI] and concurrent sexual relationships) with conditional logistic regression. Of 400 SGM who initiated PrEP, 206 were eligible for analysis, and had a median age of 24 years (IQR 22-27). In multivariable analysis, participants in the PrEP period had decreased odds of CAI (adjusted OR: 0.49, 95% CI 0.28, 0.84). PrEP use was not associated with risk compensation.

引用

页码：2807 / 2816

页数：10

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