Early recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2

被引：0

作者：

Ibtisam, Ibtisam ^{[1
]}

Kisselev, Alexei F. ^{[1
]}

机构：

[1] Auburn Univ, Harrison Coll Pharm, Dept Drug Discovery & Dev, Auburn, AL 36849 USA

来源：

ELIFE | 2024年 / 12卷

关键词：

ubiquitin; ubiquitin-binding protein; ubl doman; aspartic protease; Nrf1; Human; MULTIPLE-MYELOMA; EXPRESSION; NRF1; DEGRADATION; BORTEZOMIB; FACTOR-1; PATHWAY; STRESS; CANCER; GENES;

D O I：

10.7554/eLife.91678

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rapid recovery of proteasome activity may contribute to intrinsic and acquired resistance to FDA-approved proteasome inhibitors. Previous studies have demonstrated that the expression of proteasome genes in cells treated with sub-lethal concentrations of proteasome inhibitors is upregulated by the transcription factor Nrf1 (NFE2L1), which is activated by a DDI2 protease. Here, we demonstrate that the recovery of proteasome activity is DDI2-independent and occurs before transcription of proteasomal genes is upregulated but requires protein translation. Thus, mammalian cells possess an additional DDI2 and transcription-independent pathway for the rapid recovery of proteasome activity after proteasome inhibition.

引用

页数：14

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