Copper-Catalyzed [4+1] and [4+2] Reactions through Tandem Remote Propargylation/Cyclization/Isomerization with an Amine or a Hydrazine

被引：3

作者：

Sun, Yu-Ze ^{[1
,2
,3
]}

Lin, Guo-Qiang ^{[1
,2
]}

He, Zhi-Tao ^{[3
,4
,5
]}

机构：

[1] Shanghai Normal Univ, Dept Chem, Shanghai 200234, Peoples R China

[2] Univ Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Chem Biol, Shanghai 200032, Peoples R China

[3] Univ Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[4] Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Chem & Mat Sci, Hangzhou 310024, Peoples R China

[5] Ningbo Zhongke Creat Ctr New Mat, Ningbo 315899, Peoples R China

来源：

SYNLETT | 2025年 / 36卷 / 01期

关键词：

copper catalysis; propargylic substitution; 4+1] cyclization; 4+2] cyclization; arylhydrazines; amines; PROPARGYLIC SUBSTITUTION-REACTIONS; ENANTIOSELECTIVE PROPARGYLATION; POTENT; ESTERS; CYCLOADDITION; CONSTRUCTION; HETEROCYCLES; ANNULATION; INHIBITORS; DISCOVERY;

D O I：

10.1055/a-2294-5395

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel copper-catalyzed cyclization reactions involvinga remote propargylic substitution/cyclization/isomerization cascade aredisclosed. Derivatives of the seldomly studied heterocycles thieno[2,3-c]pyrrole and thieno[2,3-d]pyridazine are conveniently synthesized inmoderate to good yields from primary amines or arylhydrazinesthrough [4+1] and [4+2] reactions, respectively. Preliminary mechanis-tic experiments corroborated the occurrence of the designed cascadereactions

引用

页码：82 / 86

页数：5

共 61 条

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