Minimally Invasive Delivery of Percutaneous Ablation Agent via Magnetic Colloidal Hydrogel Injection for Treatment of Hepatocellular Carcinoma

被引：25

作者：

Wu, Wen-Shu ^{[1
]}

Yan, Xu ^{[1
]}

Chen, Sheng ^{[1
]}

Du, Yaxin ^{[1
]}

Hu, Jinlong ^{[2
]}

Song, Yonghong ^{[1
]}

Zha, Zhengbao ^{[1
]}

Xu, Yun-Jun ^{[3
]}

Cao, Baoqiang ^{[2
]}

Xuan, Shou-Hu ^{[4
]}

Liu, Xingyu ^{[1
]}

Chen, Bing ^{[1
]}

Dong, Liang ^{[5
]}

Lu, Yang ^{[1
]}

Yu, Shu-Hong ^{[3
]}

机构：

[1] Hefei Univ Technol, Sch Chem & Chem Engn, Anhui Prov Key Lab Adv Catalyt Mat & React Engn, Sch Food & Biol Engn, Hefei 230009, Peoples R China

[2] Anhui 2 Prov Peoples Hosp, Dept Intervent Radiol, Dept Ultrason, Dept Gen Surg, Hefei 230041, Anhui, Peoples R China

[3] Univ Sci & Technol China, New Cornerstone Sci Lab, Div Nanomat & Chem, Hefei Natl Res Ctr Phys Sci Microscale,Dept Radiol, Hefei 230026, Peoples R China

[4] Univ Sci & Technol China, CAS Ctr Excellence Complex Syst Mech, Dept Modern Mech, CAS Key Lab Mech Behav & Design Mat, Hefei 230027, Peoples R China

[5] Chinese Acad Sci, Hangzhou Inst Med HIM, Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China

来源：

ADVANCED MATERIALS | 2024年 / 36卷 / 26期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

colloidal hydrogel; hepatocellular carcinoma; magnetothermal ablation; minimally invasive; percutaneous-needle-based injectability; HYPERTHERMIA; CANCER; WATER;

D O I：

10.1002/adma.202309770

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Percutaneous thermotherapy, a minimally invasive operational procedure, is employed in the ablation of deep tumor lesions by means of target-delivering heat. Conventional thermal ablation methods, such as radiofrequency or microwave ablation, to a certain extent, are subjected to extended ablation time as well as biosafety risks of unwanted overheating. Given its effectiveness and safety, percutaneous thermotherapy gains a fresh perspective, thanks to magnetic hyperthermia. In this respect, an injectable- and magnetic-hydrogel-construct-based thermal ablation agent is likely to be a candidate for the aforementioned clinical translation. Adopting a simple and environment-friendly strategy, a magnetic colloidal hydrogel injection is introduced by a binary system comprising super-paramagnetic Fe3O4 nanoparticles and gelatin nanoparticles. The colloidal hydrogel constructs, unlike conventional bulk hydrogel, can be easily extruded through a percutaneous needle and then self-heal in a reversible manner owing to the unique electrostatic cross-linking. The introduction of magnetic building blocks is exhibited with a rapid magnetothermal response to an alternating magnetic field. Such hydrogel injection is capable of generating heat without limitation of deep penetration. The materials achieve outstanding therapeutic results in mouse and rabbit models. These findings constitute a new class of locoregional interventional thermal therapies with minimal collateral damages. The magnetic colloidal hydrogel, constructed from a binary system of biocompatible Fe3O4 nanoparticles and gelatin nanoparticles, exhibits excellent injectability and remarkable magnetically induced heating performance. Functioning as an ablation agent, the hydrogel presents the potential to integrate magnetic-medium-mediated hyperthermia therapy with minimally invasive implantation procedures, thereby introducing a novel strategy for treating hepatocellular carcinoma. image

引用

页数：14

共 55 条

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