Fabrication of Bioresorbable Barrier Membranes from Gelatin/Poly(4-Hydroxybutyrate) (P4HB)

被引:3
|
作者
Yuan, Shuaishuai [1 ]
Chen, Qi [1 ]
Guo, Manman [1 ]
Xu, Yongzhi [2 ]
Wang, Wanchun [2 ]
Li, Zhibo [1 ,3 ]
机构
[1] Qingdao Univ Sci & Technol, Coll Polymer Sci & Engn, Educ Dept, Key Lab Biobased Polymer Mat Shandong Prov, Qingdao 266042, Peoples R China
[2] Qingdao Univ, Qingdao Stomatol Hosp, Dept Stomatol, Qingdao 266003, Peoples R China
[3] Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China
基金
中国国家自然科学基金;
关键词
biodegradable; electrospun membrane; gelatin; guided bone regeneration; poly(4-hydroxybutyrate); POLY-4-HYDROXYBUTYRATE; REPAIR;
D O I
10.1002/mabi.202400036
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Dental implant surgery is a procedure that replaces damaged or missing teeth with an artificial implant. During this procedure, guided bone regeneration (GBR) membranes are commonly used to inhibit the migration of epithelium and GBR at the surgical sites. Due to its biodegradability, good biocompatibility, and unique biological properties, gelatin (GT) is considered a suitable candidate for guiding periodontal tissue regeneration. However, GT-based membranes come with limitations, such as poor mechanical strength and mismatched degradation rates. To confront this challenge, a series of GT/poly(4-hydroxybutyrate) (P4HB) composite membranes are fabricated through electrospinning technology. The morphology, composition, wetting properties, mechanical properties, biocompatibility, and in vivo biodegradability of the as-prepared composite membranes are carefully characterized. The results demonstrate that all the membranes present excellent biocompatibility. Moreover, the in vivo degradation rate of the membranes can be manipulated by changing the ratio of GT and P4HB. The results indicate that the optimized GT/P4HB membranes with a high P4HB content (75%) may be suitable for periodontal tissue engineering because of their good mechanical properties and biodegradation rate compatible with tissue growth. The gelatin/poly(4-hydroxybutyrate) membranes show excellent hemocompatibility and cytocompatibility. Moreover, the GP75 maintains its structural integrity and barrier function for 8 weeks in vivo. image
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页数:10
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