Iridium-catalyzed meta-selective C-H borylation of phenol derivatives

被引：1

作者：

Ju, Wenjie ^{[1
]}

Gao, Du ^{[1
]}

Liang, Min ^{[1
]}

Han, Shuxiong ^{[1
]}

Liu, Chuangchuang ^{[1
]}

Zhao, Yingsheng ^{[1
,2
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

[2] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453000, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2024年 / 11卷 / 12期

基金：

中国国家自然科学基金;

关键词：

AROMATIC-ALDEHYDES; DIRECTING GROUP; ACTIVATION; ARENES; COMPLEXES; LIGAND;

D O I：

10.1039/d4qo00516c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Regioselective C-H functionalization of aromatics remains a challenging problem in organic synthesis, particularly for meta-selective C-H borylations of phenols derivatives. Here, pivalic acid promoted iridium-catalyzed meta-selective C-H borylation of phenols is disclosed. Various substituted phenol directives including bioactive compounds are found to be tolerated, affording the corresponding borylated products in moderate to good yields under concise reaction conditions. Regioselective C-H functionalization of aromatics remains a challenge in synthesis, particularly for meta-selective C-H borylations of phenols. Here, pivalic acid promoted iridium-catalyzed meta-selective C-H borylation of phenols is disclosed.

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收藏

页码：3409 / 3414

页数：6

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