Carriage of Extended-Spectrum-Beta-Lactamase- and AmpC Beta-Lactamase-Producing Escherichia coli Strains from Humans and Pets in the Same Households

被引：0

作者：

Toombs-Ruane L.J. ^{[1
]}

Benschop J. ^{[1
]}

French N.P. ^{[1
]}

Biggs P.J. ^{[1
,2
]}

Midwinter A.C. ^{[1
]}

Marshall J.C. ^{[1
,2
]}

Chan M. ^{[1
]}

Drinković D. ^{[3
]}

Fayaz A. ^{[1
]}

Baker M.G. ^{[4
]}

Douwes J. ^{[5
]}

Roberts M.G. ^{[6
]}

Burgess S.A. ^{[1
]}

机构：

[1] EpiLab, School of Veterinary Science, Massey University, Palmerston North

[2] School of Fundamental Sciences, Massey University, Palmerston North

[3] Microbiology Department, North Shore Hospital, Auckland

[4] Department of Public Health, University of Otago, Wellington

[5] Centre for Public Health Research, Massey University, Wellington

[6] School of Natural and Mathematical Sciences, Massey University, Albany

来源：

Applied and Environmental Microbiology | 2020年 / 86卷 / 24期

关键词：

antibiotic resistance; Enterobacteriaceae; ESBL; Escherichia coli;

D O I：

10.1128/AEM.1613-20

中图分类号：

学科分类号：

摘要：

Extended-spectrum-beta-lactamase (ESBL)- or AmpC beta-lactamase (ACBL)-producing Escherichia coli bacteria are the most common cause of community-acquired multidrug-resistant urinary tract infections (UTIs) in New Zealand. The carriage of antimicrobial-resistant bacteria has been found in both people and pets from the same household; thus, the home environment may be a place where antimicrobial-resistant bacteria are shared between humans and pets. In this study, we sought to determine whether members (pets and people) of the households of human index cases with a UTI caused by an ESBL- or ACBL-producing E. coli strain also carried an ESBL- or ACBL-producing Enterobacteriaceae strain and, if so, whether it was a clonal match to the index case clinical strain. Index cases with a community-acquired UTI were recruited based on antimicrobial susceptibility testing of urine isolates. Fecal samples were collected from 18 non-index case people and 36 pets across 27 households. Eleven of the 27 households screened had non-index case household members (8/18 people and 5/36 animals) positive for ESBL- and/or ACBL-producing E. coli strains. Whole-genome sequence analysis of 125 E. coli isolates (including the clinical urine isolates) from these 11 households showed that within seven households, the same strain of ESBL-/ACBL-producing E. coli was cultured from both the index case and another person (5/11 households) or pet dog (2/11 households). These results suggest that transmission within the household may contribute to the community spread of ESBL- or ACBL-producing E. coli. © 2020. All Rights Reserved.

引用

页码：1 / 15

页数：14

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