Maternal immunity and antibodies to dengue virus promote infection and Zika virus-induced microcephaly in fetuses

被引：0

作者：

Rathore A.P.S. ^{[1
,2
]}

Saron W.A.A. ^{[1
]}

Lim T. ^{[1
]}

Jahan N. ^{[1
]}

St. John A.L. ^{[1
,2
,3
]}

机构：

[1] Program in Emerging Infectious Diseases, Duke-National University of Singapore, Singapore

[2] Department of Pathology, Duke University Medical Center, Durham, NC

[3] Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

来源：

Science Advances | 2020年 / 5卷 / 02期

关键词：

Viruses;

D O I：

10.1126/SCIADV.AAV3208

中图分类号：

学科分类号：

摘要：

Zika virus (ZIKV), an emergent flaviviral pathogen, has been linked to microcephaly in neonates. Although the risk is greatest during the first trimester of pregnancy in humans, timing alone cannot explain why maternal ZIKV infection leads to severe microcephaly in some fetuses, but not others. The antigenic similarities between ZIKV and dengue virus (DENV), combined with high levels of DENV immunity among ZIKV target populations in recent outbreaks, suggest that anti-DENV maternal antibodies could promote ZIKV-induced microcephaly. We demonstrated maternal-to-fetal ZIKV transmission, fetal infection, and disproportionate microcephaly in immunocompetent mice. We show that DENV-specific antibodies in ZIKV-infected pregnant mice enhance vertical ZIKV transmission and result in a severe microcephaly-like syndrome, which was dependent on the neonatal Fc receptor, FcRN. This novel immune-mediated mechanism of vertical transmission of viral infection is of special concern because ZIKV epidemic regions are also endemic to DENV. © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

引用

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