Cerebral vasculitis as a clinical manifestation of neurosarcoidosis: A scoping review

被引：1

作者：

Winter, Yaroslav ^{[1
,2
,7
]}

Groppa, Sergiu ^{[1
]}

Uphaus, Timo ^{[1
]}

Ellwardt, Erik ^{[1
,3
]}

Fuest, Sven ^{[4
]}

Meuth, Sven ^{[5
,6
]}

Bittner, Stefan ^{[1
]}

Hayani, Eyad ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Focus Program Translat Neurosci FTN, Rhine Main Neurosci Network Rmn 2, Dept Neurol,Univ Med Ctr, Mainz, Germany

[2] Philipps Univ Marburg, Dept Neurol, Baldingerstr, D-35043 Marburg, Germany

[3] Helios HSK Wiesbaden, Dept Neurol, Wiesbaden, Germany

[4] Hephata Klin, Dept Neurol, Schwalmstadt, Germany

[5] Univ Munster, Dept Neurol, Inst Translat Neurol, Munster, Germany

[6] Univ Dusseldorf, Dept Neurol, Dusseldorf, Germany

[7] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Neurol, Langenbeckstr 1, D-55131 Mainz, Germany

来源：

AUTOIMMUNITY REVIEWS | 2024年 / 23卷 / 04期

关键词：

Stroke; Vasculitis; Neurosarcoidosis; CENTRAL-NERVOUS-SYSTEM; SARCOIDOSIS; DIAGNOSIS; OUTCOMES; THERAPY;

D O I：

10.1016/j.autrev.2024.103528

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The occurrence of cerebral vasculitis in individuals with neurosarcoidosis (NS) is considered to be rare. Although the number of relevant publications has increased in recent years, evidence is mostly limited to case reports. To obtain a better understanding of this rare and severe manifestation of disease, we carried out a scoping review on cerebral vasculitis in patients diagnosed with NS. The results of the review indicate that the diagnosis of cerebral vasculitis in patients with NS is made especially in patients with systemic sarcoidosis. However, recurrent strokes in patients with NS remains the main indicator of cerebral vasculitis. A tissue biopsy is considered the gold standard to confirm the diagnosis despite occasional false-negative results. Glucocorticoids and steroid-sparing agents are the most successful current treatments. Favorable outcomes were observed with strategies targeting TNF alpha and B cells. The goal of this review is to summarize the current literature and treatment options for cerebral vasculitis in patients with NS.

引用

页数：6

共 47 条

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