Retinal Vessel Analysis and Microvascular Abnormalities in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms

被引:2
作者
Roszkowska, Anna Maria [1 ,2 ]
Leanza, Rossana [3 ]
Aragona, Emanuela [4 ]
Gargiulo, Ludovica [1 ]
Alibrandi, Angela [5 ]
Arrigo, Alessandro [4 ]
Bottaro, Adele [3 ]
Barone, Paola [3 ]
Stagno, Fabio [3 ]
Allegra, Alessandro [3 ]
机构
[1] Univ Messina, Dept Biomed Sci, Ophthalmol Unit, I-98100 Messina, Italy
[2] Andrzej Frycz Modrzewski Krakow Univ, Fac Med & Hlth Sci, Ophthalmol Dept, PL-30705 Krakow, Poland
[3] Univ Messina, Dept Human Pathol Adulthood & Childhood Gaetano Ba, Hematol Unit, Via Consolare Valeria, I-98125 Messina, Italy
[4] Ist Ricovero Cura Carattere Sci San Raffaele Sci I, I-20132 Milan, Italy
[5] Univ Messina, Dept Econ, Unit Stat & Math Sci, I-98100 Messina, Italy
关键词
Philadelphia-negative chronic myeloproliferative neoplasms; thrombosis; polycythemia vera; essential thrombocythemia; primary myelofibrosis; thrombotic risk; prognosis; retinal exams; optical coherence tomography; POLYCYTHEMIA-VERA; DIAGNOSTIC-CRITERIA; RISK-FACTORS; ATHEROSCLEROSIS; THROMBOSIS;
D O I
10.3390/jcm13082232
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Philadelphia-negative chronic myeloproliferative neoplasms are a group of clonal hematopoietic disorders including polycythemia vera, essential thrombocythemia, and primary myelofi-brosis. These neoplasms are characterized by an increased risk of thrombotic complications. Several studies have highlighted that the study of vessels of the retina offers the opportunity to visualize, in vivo, the damage to microcirculation that is common in various systemic pathologies. Methods: in our study, forty patients underwent an ophthalmological examination, using non-invasive imaging tech-niques, for analyses of their retinal vascularization. The objective was to correlate the findings ob-tained from this study of the retina with different markers of thrombotic risk, to demonstrate the usefulness of studying retinal vessels as a possible new prognostic biomarker of thrombotic risk in patients affected by Philadelphia-negative chronic myeloproliferative neoplasms. Results: retinal imaging demonstrated changes in the microcirculation, with a reduced vascular density of the deep and superficial capillary plexuses with respect to a normal group, and a correlation between retinal changes and blood parameters. Conclusions: additional research will allow us to determine whether retinal changes in individuals with chronic myeloproliferative neoplasms could be predictive of the development of thrombotic events in these subjects.
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页数:13
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