Impact of multidrug resistance on the virulence and fitness of Pseudomonas aeruginosa: a microbiological and clinical perspective

被引：17

作者：

Sendra, Elena ^{[1
]}

Fernandez-Munoz, Almudena ^{[2
]}

Zamorano, Laura ^{[2
]}

Oliver, Antonio ^{[2
,3
]}

Horcajada, Juan Pablo ^{[1
,3
]}

Juan, Carlos ^{[2
,3
]}

Gomez-Zorrilla, Silvia ^{[1
,3
]}

机构：

[1] Univ Autonoma Barcelona UAB, Univ Pompeu Fabra, Hosp Mar,Infect Pathol & Antimicrobials Res Grp IP, Hosp Mar Res Inst,CEXS,Infect Dis Serv, Passeig Maritim 25-27, Barcelona 08003, Spain

[2] Univ Hosp Son Espases, Hlth Res Inst Balear Isl IdISBa, Res Unit, Microbiology Dept, Crtra Valldemossa 79, Palma De Mallorca 07010, Spain

[3] Inst Salud Carlos III, Ctr Biomed Res Infect Dis Network CIBERINFEC, Madrid, Spain

来源：

INFECTION | 2024年 / 52卷 / 04期

关键词：

Pseudomonas aeruginosa; Multidrug resistance; Virulence; Fitness; Biological cost; Difficult to treat resistance; Antibiotic resistance; BLOOD-STREAM INFECTIONS; III SECRETION SYSTEM; VENTILATOR-ASSOCIATED PNEUMONIA; GRAM-NEGATIVE BACILLI; RISK-FACTORS; ANTIBIOTIC-RESISTANCE; ANTIMICROBIAL RESISTANCE; IN-VITRO; BETA-LACTAMASES; MEXCD-OPRJ;

D O I：

10.1007/s15010-024-02313-x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Pseudomonas aeruginosa is one of the most common nosocomial pathogens and part of the top emergent species associated with antimicrobial resistance that has become one of the greatest threat to public health in the twenty-first century. This bacterium is provided with a wide set of virulence factors that contribute to pathogenesis in acute and chronic infections. This review aims to summarize the impact of multidrug resistance on the virulence and fitness of P. aeruginosa. Although it is generally assumed that acquisition of resistant determinants is associated with a fitness cost, several studies support that resistance mutations may not be associated with a decrease in virulence and/or that certain compensatory mutations may allow multidrug resistance strains to recover their initial fitness. We discuss the interplay between resistance profiles and virulence from a microbiological perspective but also the clinical consequences in outcomes and the economic impact.

引用

页码：1235 / 1268

页数：34

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