Effect of electroconvulsive therapy on brain functional network in major depressive disorder

被引：0

作者：

Tian S. ^{[1
,2
,3
,4
]}

Xu G. ^{[1
,2
,3
]}

Yang X. ^{[1
,2
,3
]}

Paul B.F. ^{[5
]}

Alan W. ^{[6
,7
,8
]}

机构：

[1] Key Laboratory of Bioelectromagnetic and Neural Engineering of Hebei Province, Hebei University of Technology, 300401, Tianjin

[2] Tianjin Key Laboratory of Bioelectricity and Intelligent Health, Hebei University of Technology, 300401, Tianjin

[3] State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, 300130, Tianjin

[4] National Institute on Drug Dependence, Peking University, 100191, Beijing

[5] School of Medicine and Psychology, The Australian National University, Canberra

[6] Auckland Bioengineering Institute, University of Auckland, 1010, Auckland

[7] Faculty of Medical and Health Sciences, University of Auckland, 1023, Auckland

[8] Centre for Brain Research, University of Auckland, 1042, Auckland

来源：

Shengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering | 2023年 / 40卷 / 03期

关键词：

Brain functional network; Electroconvulsive therapy; Major depressive disorder; Minimum spanning tree; Resting-state electroencephalogram;

D O I：

10.7507/1001-5515.202201032

中图分类号：

学科分类号：

摘要：

电休克治疗（ECT）是一种能够对重度抑郁症（MDD）进行高效神经调节的干预技术，但其抗抑郁作用机制尚不明确。本文通过记录19例MDD患者在ECT前后的静息状态脑电（RS-EEG），从多角度分析了ECT对MDD患者静息态脑功能网络的调制作用：利用Welch算法估算自发脑电活动功率谱密度（PSD）；基于虚部相干（iCoh）构建脑功能网络并计算功能连通性；利用最小生成树理论探究脑功能网络的拓扑结构特征。结果表明，MDD患者多个节律PSD、功能连通性和拓扑结构在ECT后发生了显著变化。本文研究结果揭示了ECT对MDD患者大脑活动的作用，对MDD的临床治疗和机制解析具有重要参考作用。.; Electroconvulsive therapy (ECT) is an interventional technique capable of highly effective neuromodulation in major depressive disorder (MDD), but its antidepressant mechanism remains unclear. By recording the resting-state electroencephalogram (RS-EEG) of 19 MDD patients before and after ECT, we analyzed the modulation effect of ECT on the resting-state brain functional network of MDD patients from multiple perspectives: estimating spontaneous EEG activity power spectral density (PSD) using Welch algorithm; constructing brain functional network based on imaginary part coherence (iCoh) and calculate functional connectivity; using minimum spanning tree theory to explore the topological characteristics of brain functional network. The results show that PSD, functional connectivity, and topology in multiple frequency bands were significantly changed after ECT in MDD patients. The results of this study reveal that ECT changes the brain activity of MDD patients, which provides an important reference in the clinical treatment and mechanism analysis of MDD.

引用

页码：426 / 433

页数：7