Clinical Significance of Antibodies to DFS70 in Immunoinflammatory Rheumatic Diseases

被引：0
|
作者：
Panafidina, T. A. [1 ]
Verizhnikova, Zh. G. [1 ]
Avdeeva, A. S. [1 ]
Popkova, T. V. [1 ]
Nasonov, E. L. [1 ,2 ]
机构：
[1] Nasonova Res Inst Rheumatol, Moscow, Russia
[2] Sechenov First Moscow State Med Univ, Sechenov Univ, Minist Hlth Russian Federat, Moscow, Russia
来源：
DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2024年 / 517卷 / 01期
关键词：
immunoinflammatory rheumatic diseases; anti-DFS70; antinuclear antibodies; indirect immunofluorescence assay on HEp-2 cells; DENSE FINE SPECKLES; CLASSIFICATION CRITERIA; ANTI-DFS70; ANTIBODIES; AMERICAN-COLLEGE; HEALTHY-INDIVIDUALS; AUTOANTIBODIES; PREVALENCE; CONSENSUS; SURVIVAL;
D O I：
10.1134/S1607672924700911
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The relevance of the problem of immunoinflammatory rheumatic diseases (IIRD) for modern medicine is determined by their high prevalence in the population, the difficulty of early diagnosis, the rapid development of disability and poor life prognosis. Recent data on the significance of anti-DFS70 have opened up new possibilities for optimizing the step-by-step diagnosis of IIRD. The detection of these antibodies can help in the interpretation of a positive result for antinuclear antibodies (ANA) by indirect immunofluorescence assay on HEp-2 cells (IIFA-HEp-2) in the absence of autoantibodies specific for IIRD. Detection of anti-DFS70 in antinuclear factor (ANF) seropositive patients without clinical and/or serological markers characteristic of a certain disease from the IIRD group can be considered as a potential marker that excludes this group of diseases.
引用
收藏
页码：207 / 213
页数：7
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