Construction of Sodium alginate/palladium Nanoparticles SA/Pd NPs Aerogel for in vitro and in vivo Antibacterial and Wound Healing Applications

Bacterial infections and severe wound inflammation pose significant risks to human health and can result in fatal outcomes, particularly in cases of extensive skin damage. Therefore, the development of effective and efficient strategies for rapid wound healing and bacterial elimination is of utmost importance. In this study, we prepared a new multifunctional aerogel composed of sodium alginate/palladium nanoparticles (SA/Pd NPs) using a crosslinking process and freeze-drying cycle. The aerogel exhibited a three-dimensional structure and was designed to prevent bacterial infections and promote wound healing. To analyze the morphology, structure, and properties of the Pd NPs and aerogel composites, various characterization techniques such as UV-vis, FT-IR, SEM, and XRD were employed. Notably, the aerogel demonstrated a swelling capacity of up to 200% and a good biocompatibility. In vitro experiments confirmed that the SA/Pd NPs aerogel exhibited excellent antibacterial activity, effectively inhibiting bacterial growth against multi-drug resistant (MDR) bacterial strains. Furthermore, in vivo experiments were conducted to evaluate the wound healing and antibacterial properties of the SA/Pd NPs aerogel. The results demonstrated that the aerogel effectively promoted wound healing and prevented bacterial infections. Overall, these findings have significant potential in advancing wound healing strategies and combating bacterial skin infections.