Persistence of Anti-SARS-CoV-2 Antibodies Six Months after Infection in an Outbreak with Five Hundred COVID-19 Cases in Borriana (Spain): A Prospective Cohort Study

被引：8

作者：

Domenech-Montoliu, Salvador ^{[1
]}

Puig-Barbera, Joan ^{[2
]}

Pac-Sa, Maria Rosario ^{[3
]}

Vidal-Utrillas, Paula ^{[4
]}

Latorre-Poveda, Marta ^{[1
]}

Del Rio-Gonzalez, Alba ^{[4
]}

Ferrando-Rubert, Sara ^{[4
]}

Ferrer-Abad, Gema ^{[4
]}

Sanchez-Urbano, Manuel ^{[1
]}

Aparisi-Esteve, Laura ^{[5
]}

Badenes-Marques, Gema ^{[1
]}

Cervera-Ferrer, Belen ^{[1
]}

Clerig-Arnau, Ursula ^{[1
]}

Dols-Bernad, Claudia ^{[6
]}

Fontal-Carcel, Maria ^{[7
]}

Gomez-Lanas, Lorna ^{[1
]}

Jovani-Sales, David ^{[5
]}

Leon-Domingo, Maria Carmen ^{[8
]}

Llopico-Vilanova, Maria Dolores ^{[1
]}

Moros-Blasco, Mercedes ^{[5
]}

Notari-Rodriguez, Cristina ^{[1
]}

Ruiz-Puig, Raquel ^{[1
]}

Valls-Lopez, Sonia ^{[1
]}

Arnedo-Pena, Alberto ^{[3
,9
,10
]}

机构：

[1] Hosp Plana, Emergency Serv, Villarreal 12540, Spain

[2] Vaccines Res Area FISABIO, Valencia 46020, Spain

[3] Publ Hlth Ctr, Castellon de La Plana 12540, Spain

[4] Hlth Ctr I & II, Borriana 12540, Spain

[5] Carinyena Hlth Ctr, Vila Real 12540, Spain

[6] Hlth Ctr, Onda 12540, Spain

[7] Hlth Ctr, La Vall Duixo 12540, Spain

[8] Villa Fatima Sch, Hlth Dept 3, Borriana 12530, Spain

[9] Univ Publ Navarra, Dept Hlth Sci, Pamplona 31006, Spain

[10] Epidemiol & Publ Hlth, CIBERESP, Madrid 28029, Spain

来源：

COVID | 2021年 / 1卷 / 01期

关键词：

SARS-CoV-2; COVID-19; antibodies; cohort; population-based; body mass index; ECLIA; NEUTRALIZING ANTIBODIES; SARS-COV-2; PREVALENCE; ASSAYS;

D O I：

10.3390/covid1010006

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In March 2020, several mass gathering events were related to the Falles festival in Borriana (Spain), resulting in a 536 laboratory-confirmed COVID-19 cases outbreak among participants. This article estimates anti-SARS-CoV-2 antibodies persistence six months after and factors associated with antibody response. A prospective population-based cohort study was carried out by the Public Health Centre of Castellon and the Emergency and Clinical Analysis and Microbiology Services of Hospital de la Plana in Vila-real. In October 2020, a seroepidemiologic study was used to estimate the persistence of anti-SARS-CoV-2 antibodies against nucleocapsid protein (N) by an electrochemiluminescence immunoassay (ECLIA) was implemented. We enrolled 484 (90.2%) of the 536 members of the initial outbreak cohort and detected persistent antibodies in 479 (99%) without reinfection episodes. Five participants had a negative antibody test. Factors associated with a negative result were a lower body mass index (BMI), and less contact with other COVID-19 cases. Among the 469 participants with two ECLIA tests, 96 (20.5%) had an increase of antibodies and 373 (79.5%) a decline. Increased antibodies were associated with older age, higher BMI, more severe illness, and low current smokers. Our results show that after a COVID-19 infection, a high proportion of cases maintain detectable anti-SARS-CoV-2 antibodies.

引用

页码：71 / 82

页数：12

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