Lipid-mediated protein corona regulation with increased apolipoprotein A-I recruitment for glioma targeting

被引:16
作者
Zhang, Yiwei [1 ]
Xiao, Wei [1 ]
He, Siqin [1 ]
Xia, Xue [1 ]
Yang, Wenqin [1 ]
Yang, Zhihang [1 ]
Hu, Haili [1 ]
Wang, Yushan [1 ]
Wang, Xiaorong [1 ]
Li, Hanmei [2 ]
Huang, Yuan [1 ]
Gao, Huile [1 ]
机构
[1] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist, Chengdu 610041, Peoples R China
[2] Chengdu Univ, Sch Food & Biol Engn, Chengdu 610106, Peoples R China
基金
中国国家自然科学基金;
关键词
Protein Corona; Apolipoprotein A-I; Lipid; Brain-targeting; Glioma-targeting; BLOOD-BRAIN-BARRIER; DRUG-DELIVERY; NANOPARTICLES; PACLITAXEL; PLASMA; IMPACT;
D O I
10.1016/j.jconrel.2024.02.020
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Protein corona has long been a source of concern, as it might impair the targeting efficacy of targeted drug delivery systems. However, engineered up-regulating the adsorption of certain functional serum proteins could provide nanoparticles with specific targeting drug delivery capacity. Herein, apolipoprotein A-I absorption increased nanoparticles (SPC-PLGA NPs), composed with the Food and Drug Administration approved intravenously injectable soybean phosphatidylcholine (SPC) and poly (DL-lactide-co-glycolide) (PLGA), were fabricated for enhanced glioma targeting. Due to the high affinity of SPC and apolipoprotein A-I, the percentage of apolipoprotein A-I in the protein corona of SPC-PLGA NPs was 2.19-fold higher than that of nanoparticles without SPC, which made SPC-PLGA NPs have superior glioma targeting ability through binding to scavenger receptor class B-I on blood-brain barrier and glioma cells both in vitro and in vivo. SPC-PLGA NPs loaded with paclitaxel could effectively reduce glioma invasion and prolong the survival time of glioma-bearing mice. In conclusion, we provided a good example of the direction of achieving targeting drug delivery based on protein corona regulation.
引用
收藏
页码:42 / 51
页数:10
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