Recent advances in the treatment of pancreatic cancer

Pancreatic cancer (PC) is one of the most aggressive gastrointestinal malignancies, characterized by rapid progression and early onset of metastasis, leading to a dismal prognosis for patients. In the recent past, substantial progress has been conducted recently in managing PC, encompassing various treatment modalities such as chemotherapy, neoadjuvant therapy, targeted therapy, and immunotherapy. Particularly in 2023, several noteworthy studies have contributed to optimizing neoadjuvant treatment regimens and exploring novel approaches that involve targeted therapies and immunotherapies for PC. These advancements hold promise for improving overall survival outcomes and enhancing quality of life for patients with pancreatic cancer. This commentary summarizes the new advances in systemic therapy for pancreatic cancer in 2023.