Next-generation sequencing of primary testicular lymphoma and relapse in the glans penis after prophylactic radiation therapy: a rare case report

被引：0

作者：

Ishibashi, Naoya ^{[1
,4
]}

Nakanishi, Yoko ^{[2
]}

Maebayashi, Toshiya ^{[1
]}

Miura, Katsuhiro ^{[3
]}

Ohni, Sumie ^{[2
]}

Masuda, Shinobu ^{[2
]}

Amano, Yasuo ^{[4
]}

Okada, Masahiro ^{[1
]}

机构：

[1] Nihon Univ, Sch Med, Dept Radiol, 30-1 Oyaguchi Kami Cho,Itabashi, Tokyo 1738610, Japan

[2] Nihon Univ, Sch Med, Dept Oncol Pathol, Itabashi, Tokyo 1738610, Japan

[3] Nihon Univ, Sch Med, Dept Med, Div Hematol & Rheumatol, Itabashi, Tokyo 1738610, Japan

[4] Nihon Univ Hosp, Dept Radiol, Chiyoda, Tokyo 1018309, Japan

来源：

DIAGNOSTIC PATHOLOGY | 2024年 / 19卷 / 01期

关键词：

Next-generation sequencing; Primary testicular lymphoma; Glans penis; Radiation therapy; Case report; CELL LYMPHOMA; TESTIS;

D O I：

10.1186/s13000-024-01498-x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Background Primary testicular lymphoma (PTL) is relatively rare. The contralateral testis is a common site of PTL relapse; therefore, once complete remission is achieved, radiation therapy (RT) is administered to the contralateral testis to prevent relapse.Case presentation A 76-year-old man was diagnosed with PTL and received RT as described above. However, despite achieving and maintaining complete remission, a mass diagnosed as diffuse large B-cell lymphoma by tissue biopsy developed in the glans penis 6.5 years after prophylactic RT. We investigated whether the glans penile lymphoma was PTL relapse or a new malignancy by genomic analysis using next-generation sequencing of DNA extracted from two histopathological specimens.Conclusions We found the same variant allele fraction in four somatic genes (MYD88, IL7R, BLNK, and FLT3) at similar frequencies, indicating that the glans penile lymphoma had the same origin as the PTL. To the best of our knowledge, this is the first case report of PTL relapse in the glans penis.

引用

页数：6

共 26 条

[1] Primary lymphoma of the penis: Diagnosis and treatment [J].