Vascular Endothelial Growth Factor and Ischemic Stroke Risk: A Mendelian Randomization Study

被引:0
作者
Zhang, Xiao [1 ,2 ,3 ]
Hu, Xinzhi [4 ]
Fang, Shiyuan [4 ,5 ]
Li, Jiayao [1 ,3 ]
Liu, Zhichao [2 ]
Xie, Weidun [6 ]
Xu, Ran [1 ,3 ]
Dmytriw, Adam A. [7 ]
Yang, Kun [8 ]
Ma, Yan [1 ,3 ]
Jiao, Liqun [1 ,3 ,9 ]
Wang, Tao [1 ,3 ]
机构
[1] Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, 45 Changchun St, Beijing 100053, Peoples R China
[2] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England
[3] China Int Neurosci Inst China INI, 45 Changchun St, Beijing 100053, Peoples R China
[4] Peking Union Med Coll & Chinese Acad Med Sci, Beijing 100730, Peoples R China
[5] Peking Union Med Coll Hosp, Dept Neurol, Beijing 100730, Peoples R China
[6] City Univ Hong Kong, Dept Comp Sci, Kowloon, Hong Kong 999077, Peoples R China
[7] Massachusetts Gen Hosp, Neuroendovasc Program, Boston, MA 02114 USA
[8] Taian Cent Hosp, Dept Neurosurg, 29 Longtan Rd, Tai An 271000, Shandong, Peoples R China
[9] Capital Med Univ, Xuanwu Hosp, Dept Intervent Neuroradiol, 45 Changchun St, Beijing 100053, Peoples R China
关键词
Vascular endothelial growth factor; Ischemic stroke; Causal association; Mendelian randomization; Stroke prevention; Causal link; INSTRUMENTS; DISEASE;
D O I
10.1007/s40120-024-00601-0
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction Previous studies have reported controversial relationships between circulating vascular endothelial growth factors (VEGF) and ischemic stroke (IS). This study aims to demonstrate the causal effect between VEGF and IS using Mendelian randomization (MR).Methods Summary statistics data from two large-scale genome-wide association studies (GWAS) for 16,112 patients with measured VEGF levels and 40,585 patients with IS were downloaded from public databases and included in this study. A published calculator was adopted for MR power calculation. The primary outcome was any ischemic stroke, and the secondary outcomes were large-artery stroke, cardioembolic stroke, and small-vessel stroke. We used the inverse variance-weighted (IVW) method for primary analysis, supplemented by MR-Egger regression and the weighted median method.Results Nine SNPs were included to represent serum VEGF levels. The IVW method revealed no strong causal association between VEGF and any ischemic stroke (odds ratio [OR] 1.01, 95% CI 0.99-1.04, p = 0.39), cardioembolic stroke (OR 1.04, 95% CI 0.97-1.12, p = 0.28), large-artery stroke (OR 1.02, 95% CI 0.95-1.09, p = 0.62), and small-vessel stroke (OR 0.98, 95% CI 0.91-1.04, p = 0.46). These findings remained robust in sensitivity analyses. MR-Egger regression suggested no horizontal pleiotropy.Conclusions This Mendelian randomization study found no relationship between genetically predisposed serum VEGF levels and risks of IS or its subtypes.
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页码:727 / 737
页数:11
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