Macular Hole;
Full Thickness Macular Hole;
Spontaneous Closure;
Time Course;
Re-opening;
Watch and Wait;
OPTICAL COHERENCE TOMOGRAPHY;
INTERNAL LIMITING MEMBRANE;
VITREOMACULAR TRACTION;
OCRIPLASMIN;
ADHESION;
SURGERY;
STAGE-2;
D O I:
10.1007/s00417-024-06465-2
中图分类号:
R77 [眼科学];
学科分类号:
100212 ;
摘要:
Purpose Spontaneous closure of idiopathic full-thickness macular holes (iFTMH) has been reported regularly. However, little is known about its probability and timeline. Methods In this retrospective study all consecutive patients who presented between August 2008 and August 2019 were screened for the presence of a macular hole and only iFTMHs were included. The primary outcome measure was the spontaneous closure of the iFTMH. Results Of 1256 eyes with macular holes, 338 fulfilled the inclusion criteria. Spontaneous closure of the iFTMH was detected in 31 eyes (9.2%) with a median time of 44 days after diagnosis. Eyes exhibiting spontaneous closure demonstrated a higher baseline best-corrected visual-acuity (BCVA) and smaller iFTMH diameter (p < 0.0001 and p < 0.0001, respectively). The mean BCVA improved from 0.4 logMAR (SD +/- 0.21) to 0.29 logMAR (SD +/- 0.20) after spontaneous closure (p = 0.031). The iFTMH diameter was positively correlated with the time to spontaneous closure (Pearson-r = 0.37, p = 0.0377). Spontaneously closed iFTMHs reopened in 16% (n = 5) of cases, with a median of 136 days after closure. A logistic regression model showed the hole diameter was associated with spontaneous closure (odds-Ratio 0.97, 95%CI [0.96, 0.98]). The Kaplan-Meier-Curve revealed that approximately 25% of small-iFTMH (n = 124) and 55% of iFTMH with a diameter < 150<mu>m (n = 48) closed spontaneously within two months. Conclusion The established gold-standard for the treatment of iFTMHs is macular surgery. However, the potential for spontaneous closure of small iFTMHs must be acknowledged. Therefore, if surgical treatment is delayed in individual cases, close observation is recommended.
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页码:2859 / 2865
页数:7
相关论文
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[1]
Alsakran Wael A, 2019, Am J Ophthalmol Case Rep, V13, P154, DOI 10.1016/j.ajoc.2019.01.003
机构:
Department of Ophthalmology, Hospices Civils de Lyon, University Hospital, Claude Bernard Lyon I UniversityService d'Ophtalmologie, Pôle Médecine Interne-Ophtalmologie-ORL, CHU Clermont-Ferrand
Cornut P.-L.
Chaise F.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Ophthalmology, Hospices Civils de Lyon, University Hospital, Claude Bernard Lyon I UniversityService d'Ophtalmologie, Pôle Médecine Interne-Ophtalmologie-ORL, CHU Clermont-Ferrand
Chaise F.
Labeille E.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Ophthalmology, Hospices Civils de Lyon, University Hospital, Claude Bernard Lyon I UniversityService d'Ophtalmologie, Pôle Médecine Interne-Ophtalmologie-ORL, CHU Clermont-Ferrand
Labeille E.
Manificat H.J.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Ophthalmology, Hospices Civils de Lyon, University Hospital, Claude Bernard Lyon I UniversityService d'Ophtalmologie, Pôle Médecine Interne-Ophtalmologie-ORL, CHU Clermont-Ferrand
Manificat H.J.
Feldman A.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Ophthalmology, Hospices Civils de Lyon, University Hospital, Claude Bernard Lyon I UniversityService d'Ophtalmologie, Pôle Médecine Interne-Ophtalmologie-ORL, CHU Clermont-Ferrand
Feldman A.
Perard L.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Internal Medicine, Edouard-Herriot Hospital, Lyon 69008, place d'ArsonvalService d'Ophtalmologie, Pôle Médecine Interne-Ophtalmologie-ORL, CHU Clermont-Ferrand
机构:
Department of Ophthalmology, Hospices Civils de Lyon, University Hospital, Claude Bernard Lyon I UniversityService d'Ophtalmologie, Pôle Médecine Interne-Ophtalmologie-ORL, CHU Clermont-Ferrand
机构:
Retina Consultants Arizona, Phoenix, AZ USA
Univ Southern Calif, Keck Sch Med, USC Roski Eye Inst, Los Angeles, CA USARetina Consultants Arizona, Phoenix, AZ USA
Dugel, Pravin U.
Tolentino, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Retina & Macular Dis, Winter Haven, FL USA
Univ Cent Florida, Orlando, FL 32816 USARetina Consultants Arizona, Phoenix, AZ USA
Tolentino, Michael
Feiner, Leonard
论文数: 0引用数: 0
h-index: 0
机构:
Hackensack Univ, Med Ctr, Hackensack, NJ USA
NJ Retina, Ridgewood, NJ USARetina Consultants Arizona, Phoenix, AZ USA
Feiner, Leonard
Kozma, Petra
论文数: 0引用数: 0
h-index: 0
机构:
ThromboGenics NV, Leuven, BelgiumRetina Consultants Arizona, Phoenix, AZ USA
Kozma, Petra
Leroy, Annick
论文数: 0引用数: 0
h-index: 0
机构:
ThromboGenics NV, Leuven, BelgiumRetina Consultants Arizona, Phoenix, AZ USA
机构:
Tufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USATufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Duker, Jay S.
Kaiser, Peter K.
论文数: 0引用数: 0
h-index: 0
机构:
Cleveland Clin, Cole Eye Inst, Cleveland, OH 44106 USATufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Kaiser, Peter K.
Binder, Susanne
论文数: 0引用数: 0
h-index: 0
机构:
Ludwig Boltzmann Inst Retinol & Biomicroscop Lase, Vienna, Austria
Rudolph Fdn Clin, Dept Ophthalmol, Vienna, AustriaTufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Binder, Susanne
de Smet, Marc D.
论文数: 0引用数: 0
h-index: 0
机构:
MIOS, Specialized Eye Ctr, Retina & Inflammat Unit, Lausanne, SwitzerlandTufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
de Smet, Marc D.
Gaudric, Alain
论文数: 0引用数: 0
h-index: 0
机构:
Hop Lariboisiere, Dept Ophthalmol, F-75475 Paris, FranceTufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Gaudric, Alain
Reichel, Elias
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USATufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Reichel, Elias
Sadda, SriniVas R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Doheny Eye Inst, Los Angeles, CA 90033 USATufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Sadda, SriniVas R.
Sebag, Jerry
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Doheny Eye Inst, Los Angeles, CA 90033 USA
VMR Inst, Huntington Beach, CA USATufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Sebag, Jerry
Spaide, Richard F.
论文数: 0引用数: 0
h-index: 0
机构:
Vitreous Retina Macula Consultants New York, New York, NY USATufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Spaide, Richard F.
Stalmans, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Katholieke Univ Leuven Hosp, Dept Ophthalmol, Louvain, BelgiumTufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
机构:
Department of Ophthalmology, Hospices Civils de Lyon, University Hospital, Claude Bernard Lyon I UniversityService d'Ophtalmologie, Pôle Médecine Interne-Ophtalmologie-ORL, CHU Clermont-Ferrand
Cornut P.-L.
Chaise F.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Ophthalmology, Hospices Civils de Lyon, University Hospital, Claude Bernard Lyon I UniversityService d'Ophtalmologie, Pôle Médecine Interne-Ophtalmologie-ORL, CHU Clermont-Ferrand
Chaise F.
Labeille E.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Ophthalmology, Hospices Civils de Lyon, University Hospital, Claude Bernard Lyon I UniversityService d'Ophtalmologie, Pôle Médecine Interne-Ophtalmologie-ORL, CHU Clermont-Ferrand
Labeille E.
Manificat H.J.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Ophthalmology, Hospices Civils de Lyon, University Hospital, Claude Bernard Lyon I UniversityService d'Ophtalmologie, Pôle Médecine Interne-Ophtalmologie-ORL, CHU Clermont-Ferrand
Manificat H.J.
Feldman A.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Ophthalmology, Hospices Civils de Lyon, University Hospital, Claude Bernard Lyon I UniversityService d'Ophtalmologie, Pôle Médecine Interne-Ophtalmologie-ORL, CHU Clermont-Ferrand
Feldman A.
Perard L.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Internal Medicine, Edouard-Herriot Hospital, Lyon 69008, place d'ArsonvalService d'Ophtalmologie, Pôle Médecine Interne-Ophtalmologie-ORL, CHU Clermont-Ferrand
机构:
Department of Ophthalmology, Hospices Civils de Lyon, University Hospital, Claude Bernard Lyon I UniversityService d'Ophtalmologie, Pôle Médecine Interne-Ophtalmologie-ORL, CHU Clermont-Ferrand
机构:
Retina Consultants Arizona, Phoenix, AZ USA
Univ Southern Calif, Keck Sch Med, USC Roski Eye Inst, Los Angeles, CA USARetina Consultants Arizona, Phoenix, AZ USA
Dugel, Pravin U.
Tolentino, Michael
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Retina & Macular Dis, Winter Haven, FL USA
Univ Cent Florida, Orlando, FL 32816 USARetina Consultants Arizona, Phoenix, AZ USA
Tolentino, Michael
Feiner, Leonard
论文数: 0引用数: 0
h-index: 0
机构:
Hackensack Univ, Med Ctr, Hackensack, NJ USA
NJ Retina, Ridgewood, NJ USARetina Consultants Arizona, Phoenix, AZ USA
Feiner, Leonard
Kozma, Petra
论文数: 0引用数: 0
h-index: 0
机构:
ThromboGenics NV, Leuven, BelgiumRetina Consultants Arizona, Phoenix, AZ USA
Kozma, Petra
Leroy, Annick
论文数: 0引用数: 0
h-index: 0
机构:
ThromboGenics NV, Leuven, BelgiumRetina Consultants Arizona, Phoenix, AZ USA
机构:
Tufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USATufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Duker, Jay S.
Kaiser, Peter K.
论文数: 0引用数: 0
h-index: 0
机构:
Cleveland Clin, Cole Eye Inst, Cleveland, OH 44106 USATufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Kaiser, Peter K.
Binder, Susanne
论文数: 0引用数: 0
h-index: 0
机构:
Ludwig Boltzmann Inst Retinol & Biomicroscop Lase, Vienna, Austria
Rudolph Fdn Clin, Dept Ophthalmol, Vienna, AustriaTufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Binder, Susanne
de Smet, Marc D.
论文数: 0引用数: 0
h-index: 0
机构:
MIOS, Specialized Eye Ctr, Retina & Inflammat Unit, Lausanne, SwitzerlandTufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
de Smet, Marc D.
Gaudric, Alain
论文数: 0引用数: 0
h-index: 0
机构:
Hop Lariboisiere, Dept Ophthalmol, F-75475 Paris, FranceTufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Gaudric, Alain
Reichel, Elias
论文数: 0引用数: 0
h-index: 0
机构:
Tufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USATufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Reichel, Elias
Sadda, SriniVas R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Doheny Eye Inst, Los Angeles, CA 90033 USATufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Sadda, SriniVas R.
Sebag, Jerry
论文数: 0引用数: 0
h-index: 0
机构:
Univ So Calif, Keck Sch Med, Doheny Eye Inst, Los Angeles, CA 90033 USA
VMR Inst, Huntington Beach, CA USATufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Sebag, Jerry
Spaide, Richard F.
论文数: 0引用数: 0
h-index: 0
机构:
Vitreous Retina Macula Consultants New York, New York, NY USATufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
Spaide, Richard F.
Stalmans, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Katholieke Univ Leuven Hosp, Dept Ophthalmol, Louvain, BelgiumTufts Univ, Sch Med, Tufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA