Primary Management of Operable Locally Advanced Oral Cavity Squamous Cell Carcinoma: Current Concepts and Strategies

被引：4

作者：

Asarkar, Ameya A. ^{[1
]}

Chang, Brent A. ^{[2
]}

de Bree, Remco ^{[3
]}

Kowalski, Luiz P. ^{[4
,5
]}

Guntinas-Lichius, Orlando ^{[6
]}

Bradley, Patrick J. ^{[7
]}

de Graaf, Pim ^{[8
,9
]}

Strojan, Primoz ^{[10
]}

Rao, Karthik N. ^{[11
]}

Makitie, Antti A. ^{[12
,13
]}

Lopez, Fernando ^{[14
]}

Rinaldo, Alessandra ^{[15
]}

Palme, Carsten ^{[16
,17
]}

Genden, Eric M. ^{[18
]}

Sanabria, Alvaro ^{[19
]}

Rodrigo, Juan P. ^{[20
]}

Ferlito, Alfio ^{[21
]}

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Shreveport, LA 71103 USA

[2] Dept Otolaryngol Head & Neck Surg, Mayo Clin Arizona, Phoenix, AZ USA

[3] Univ Med Ctr Utrecht, UMC Utrecht Canc Ctr, Dept Head & Neck Surg Oncol, Utrecht, Netherlands

[4] Univ Sao Paulo, Med Sch, Head & Neck Surg Dept, Sao Paulo, Brazil

[5] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo, Brazil

[6] Jena Univ Hosp, Inst Phoniatry & Pedaudiol, Dept Otorhinolaryngol, Jena, Germany

[7] Nottingham Univ Hosp, Queens Med Ctr Campus, Dept ORLHNS, Derby Rd, Nottingham NG7 2UH, England

[8] Vrije Univ Amsterdam, Radiol & Nucl Med, Amsterdam UMC Locat, de Boelelaan 1117, Amsterdam, Netherlands

[9] Canc Ctr Amsterdam, Imaging & Biomarkers, Amsterdam, Netherlands

[10] Inst Oncol, Dept Radiat Oncol, Ljubljana 1000, Slovenia

[11] Sri Shankara Canc Hosp & Res Ctr, Dept Head & Neck Oncol, Bangalore, India

[12] Univ Helsinki, Dept Otorhinolaryngol Head & Neck Surg, Res Program Syst Oncol, Fac Med, Helsinki, Finland

[13] Helsinki Univ Hosp, Helsinki, Finland

[14] Hosp Univ Cent Asturias, ENT & Head & Neck Dept, Oviedo, Spain

[15] ENT Unit, Policlin Citta Udine, I-33100 Udine, Italy

[16] Sydney Head & Neck Canc Inst, Chris OBrien Lifehouse, Sydney, NSW, Australia

[17] Univ Sydney, Fac Med & Hlth, Sydney Med Sch, Sydney, NSW, Australia

[18] Mt Sinai Med Ctr, Dept Otolaryngol Head & Neck Surg, New York, NY 10029 USA

[19] Univ Antioquia, Ctr Excelencia Cirugia Cabeza & Cuello, Sch Med, Dept Surg, Medellin, Colombia

[20] Univ Oviedo, Hosp Univ Cent Asturias, Dept Otolaryngol, IUOPA,CIBERONC, Oviedo 33011, Spain

[21] Int Head & Neck Sci Grp, I-35030 Padua, Italy

来源：

ADVANCES IN THERAPY | 2024年 / 41卷 / 06期

关键词：

Oral cavity squamous cell carcinoma; TNM; Margins; Neoadjuvant chemotherapy; surgery; QUALITY-OF-LIFE; BUCCAL MUCOSA CANCER; CONCURRENT CHEMORADIOTHERAPY; ADJUVANT RADIOTHERAPY; COMPARTMENTAL SURGERY; PERINEURAL SPREAD; HEAD; MARGIN; OUTCOMES; CT;

D O I：

10.1007/s12325-024-02861-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

IntroductionLocally advanced oral cavity carcinoma (LAOCSCC) is primarily treated with surgery followed by radiotherapy with or without chemotherapy.MethodsA review of literature using PubMED was performed for studies reporting the management of LAOCSCC. Based on the reviewed literature and opinions of experts in the field, recommendations were made.ResultsStudies have shown that outcomes following resection of T4a and infranotch (inferior to mandibular notch) T4b are comparable. We discuss the concept of compartmental resection of LAOCSCC and issues concerning the management of the neck. Further, patients who refuse or are unable to undergo surgery can be treated with chemoradiotherapy with uncertain outcomes. The role of neoadjuvant chemotherapy has shown promise for organ (mandibular) preservation in a select subset of patients.ConclusionThe management strategy for LAOCSCC should be determined in a multidisciplinary setting with emphasis on tumor control, functional preservation, and quality of life of the patient.

引用

页码：2133 / 2150

页数：18

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