3D printing processes in precise drug delivery for personalized medicine

被引：29

作者：

Peng, Haisheng ^{[1
]}

Han, Bo ^{[2
]}

Tong, Tianjian ^{[3
]}

Jin, Xin ^{[1
]}

Peng, Yanbo ^{[4
]}

Guo, Meitong ^{[1
]}

Li, Bian ^{[1
]}

Ding, Jiaxin ^{[1
]}

Kong, Qingfei ^{[5
]}

Wang, Qun ^{[3
]}

机构：

[1] Univ Shaoxing, Med Coll, Dept Pharmacol, Shaoxing, Peoples R China

[2] Harbin Med Univ, Dept Pharm, Daqing Branch, Daqing, Peoples R China

[3] Iowa State Univ, Dept Chem & Biol Engn, Ames, IA 50011 USA

[4] China Pharmaceut Univ, Dept Pharmaceut Engn, 639 Longmian Rd, Nanjing 211198, Peoples R China

[5] Harbin Med Univ, Dept Neurobiol, Heilongjiang Prov Key Lab Neurobiol, Harbin, Heilongjiang, Peoples R China

来源：

BIOFABRICATION | 2024年 / 16卷 / 03期

基金：

中国国家自然科学基金;

关键词：

personalized medicine; 3D printing; dosage form; precise drug delivery; DEPOSITION MODELING FDM; ORAL DOSAGE FORMS; INNOVATIVE APPROACH; RELEASE; TABLETS; FABRICATION; MICRONEEDLE; EXTRUSION; POLYMERS; DEVICES;

D O I：

10.1088/1758-5090/ad3a14

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

With the advent of personalized medicine, the drug delivery system will be changed significantly. The development of personalized medicine needs the support of many technologies, among which three-dimensional printing (3DP) technology is a novel formulation-preparing process that creates 3D objects by depositing printing materials layer-by-layer based on the computer-aided design method. Compared with traditional pharmaceutical processes, 3DP produces complex drug combinations, personalized dosage, and flexible shape and structure of dosage forms (DFs) on demand. In the future, personalized 3DP drugs may supplement and even replace their traditional counterpart. We systematically introduce the applications of 3DP technologies in the pharmaceutical industry and summarize the virtues and shortcomings of each technique. The release behaviors and control mechanisms of the pharmaceutical DFs with desired structures are also analyzed. Finally, the benefits, challenges, and prospects of 3DP technology to the pharmaceutical industry are discussed.

引用

页数：36

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