Clinical relevance and advances in detection of translational biomarker cardiac troponin
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作者:
Durairaj, Brindha
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PSG Coll Arts & Sci, Dept Biochem, Civil Aerodrome Post, Coimbatore 641014, Tamil Nadu, India
PSG Coll Arts & Sci, Civil Aerodrome Post, Coimbatore 641014, IndiaPSG Coll Arts & Sci, Dept Biochem, Civil Aerodrome Post, Coimbatore 641014, Tamil Nadu, India
Durairaj, Brindha
[1
,2
]
Mohandass, Swathanthiram
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PSG Coll Arts & Sci, Dept Biochem, Civil Aerodrome Post, Coimbatore 641014, Tamil Nadu, IndiaPSG Coll Arts & Sci, Dept Biochem, Civil Aerodrome Post, Coimbatore 641014, Tamil Nadu, India
Mohandass, Swathanthiram
[1
]
Sakthivel, Kunnathur Murugesan
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PSG Coll Arts & Sci, Dept Biochem, Civil Aerodrome Post, Coimbatore 641014, Tamil Nadu, IndiaPSG Coll Arts & Sci, Dept Biochem, Civil Aerodrome Post, Coimbatore 641014, Tamil Nadu, India
Sakthivel, Kunnathur Murugesan
[1
]
Poornima, Arthanareshwarar Arunachalam
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PSG Coll Arts & Sci, Dept Biochem, Civil Aerodrome Post, Coimbatore 641014, Tamil Nadu, IndiaPSG Coll Arts & Sci, Dept Biochem, Civil Aerodrome Post, Coimbatore 641014, Tamil Nadu, India
Poornima, Arthanareshwarar Arunachalam
[1
]
机构:
[1] PSG Coll Arts & Sci, Dept Biochem, Civil Aerodrome Post, Coimbatore 641014, Tamil Nadu, India
[2] PSG Coll Arts & Sci, Civil Aerodrome Post, Coimbatore 641014, India
Cardiovascular diseases (CVD) are a range of diseases, pointing the functional hindrances in the heart and blood vessels of the human system that contributes to 48.6 % of the world 's adult death rate. The diagnosis of CVD relies upon the Electro Cardio Gram (ECG) and detection of muscle markers such as troponins. Among the cardiac trio, Cardiac Troponin I (cTnI) weighing 23 KiloDalton (kDa) is a sorted biomarker for CVD. cTnI remains high in the blood after 1 -2 weeks of myocardial damage. Testing of cTnI in CVD patients aids in diagnosis and risk stratification of the disease. Different determination systems including optical, electrochemical, and acoustic have been put forward for monitoring the cTnI which are Point of Care (POC) that promotes simple and sensitive detection of cTnI. The modern era has paved way to high-sensitivity Troponin I (hscTnI) devices that can detect up to 0.01 ng/ml in human blood/plasma/serum. Yet, the practice of hscTnI is impracticable due to cost inefficiency. Development of new hscTnI devices with minimal investment and maximal detection range will meet the global requirement. This review gives an over view on different detection systems of cardiac troponin I which stands as a translational detection molecule for CVDs.
机构:
Gen Hosp Vinkovci, Emergency Admiss Unit Lab, Vladimira Gortana 25, Vinkovci 32100, Croatia
Josip Juraj Strossmayer Univ Osijek, Fac Med, Josipa Huttlera 4, Osijek 31000, CroatiaGen Hosp Vinkovci, Emergency Admiss Unit Lab, Vladimira Gortana 25, Vinkovci 32100, Croatia
Mikic, Misel
Sestak, Anamarija
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Josip Juraj Strossmayer Univ Osijek, Fac Med, Josipa Huttlera 4, Osijek 31000, Croatia
Gen Hosp Vukovar, Dept Otorhinolaryngol, Zupanijska Ulica 35, Vukovar 32000, CroatiaGen Hosp Vinkovci, Emergency Admiss Unit Lab, Vladimira Gortana 25, Vinkovci 32100, Croatia
Sestak, Anamarija
Volaric, Mile
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Josip Juraj Strossmayer Univ Osijek, Fac Med, Josipa Huttlera 4, Osijek 31000, CroatiaGen Hosp Vinkovci, Emergency Admiss Unit Lab, Vladimira Gortana 25, Vinkovci 32100, Croatia
Volaric, Mile
Rudan, Stjepan
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Fac Dent Med & Hlth, Dept Publ Hlth, Crkvena 21, Osijek 31000, CroatiaGen Hosp Vinkovci, Emergency Admiss Unit Lab, Vladimira Gortana 25, Vinkovci 32100, Croatia
Rudan, Stjepan
Majnaric, Ljiljana Trtica
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Fac Dent Med & Hlth, Dept Publ Hlth, Crkvena 21, Osijek 31000, Croatia
Josip Juraj Strossmayer Univ Osijek, Fac Med, Dept Internal Med Family Med & Hist Med, Josipa Huttlera 4, Osijek 31000, CroatiaGen Hosp Vinkovci, Emergency Admiss Unit Lab, Vladimira Gortana 25, Vinkovci 32100, Croatia
机构:
German Canc Res Ctr, DKTK Clin Cooperat Unit CCU Neuroimmunol & Brain, Heidelberg, Germany
Heidelberg Univ, Med Fac Mannheim, Dept Neurol, MCTN, Mannheim, GermanyGerman Canc Res Ctr, DKTK Clin Cooperat Unit CCU Neuroimmunol & Brain, Heidelberg, Germany
Bunse, Theresa
Kraemer, Christopher
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German Canc Res Ctr, DKTK Clin Cooperat Unit CCU Neuroimmunol & Brain, Heidelberg, GermanyGerman Canc Res Ctr, DKTK Clin Cooperat Unit CCU Neuroimmunol & Brain, Heidelberg, Germany
Kraemer, Christopher
Chih, Yu-Chan
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German Canc Res Ctr, DKTK Clin Cooperat Unit CCU Neuroimmunol & Brain, Heidelberg, Germany
Heidelberg Univ, Fac Biosci, Heidelberg, GermanyGerman Canc Res Ctr, DKTK Clin Cooperat Unit CCU Neuroimmunol & Brain, Heidelberg, Germany