Clinical relevance and advances in detection of translational biomarker cardiac troponin

被引:2
|
作者
Durairaj, Brindha [1 ,2 ]
Mohandass, Swathanthiram [1 ]
Sakthivel, Kunnathur Murugesan [1 ]
Poornima, Arthanareshwarar Arunachalam [1 ]
机构
[1] PSG Coll Arts & Sci, Dept Biochem, Civil Aerodrome Post, Coimbatore 641014, Tamil Nadu, India
[2] PSG Coll Arts & Sci, Civil Aerodrome Post, Coimbatore 641014, India
关键词
Cardiovascular disease; Cardiac troponin I; POC diagnosis; Biosensors; Clinical diagnosis; MYOCARDIAL-INFARCTION; CHEMILUMINESCENCE IMMUNOASSAY; ELECTROCHEMICAL BIOSENSORS; VENTRICULAR DYSFUNCTION; GOLD NANOPARTICLES; EUROPEAN-SOCIETY; SKELETAL-MUSCLE; I ELEVATION; ASSAYS; DETERMINANTS;
D O I
10.1016/j.ab.2024.115505
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Cardiovascular diseases (CVD) are a range of diseases, pointing the functional hindrances in the heart and blood vessels of the human system that contributes to 48.6 % of the world 's adult death rate. The diagnosis of CVD relies upon the Electro Cardio Gram (ECG) and detection of muscle markers such as troponins. Among the cardiac trio, Cardiac Troponin I (cTnI) weighing 23 KiloDalton (kDa) is a sorted biomarker for CVD. cTnI remains high in the blood after 1 -2 weeks of myocardial damage. Testing of cTnI in CVD patients aids in diagnosis and risk stratification of the disease. Different determination systems including optical, electrochemical, and acoustic have been put forward for monitoring the cTnI which are Point of Care (POC) that promotes simple and sensitive detection of cTnI. The modern era has paved way to high-sensitivity Troponin I (hscTnI) devices that can detect up to 0.01 ng/ml in human blood/plasma/serum. Yet, the practice of hscTnI is impracticable due to cost inefficiency. Development of new hscTnI devices with minimal investment and maximal detection range will meet the global requirement. This review gives an over view on different detection systems of cardiac troponin I which stands as a translational detection molecule for CVDs.
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页数:7
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