Chitosan-based nanofibrous scaffolds for biomedical and pharmaceutical applications: A comprehensive review

被引：34

作者：

Almajidi, Yasir Qasim ^{[1
]}

Ponnusankar, Sivasankaran ^{[2
]}

Chaitanya, M. V. N. L. ^{[3
]}

Marisetti, Arya Lakshmi ^{[4
]}

Hsu, Chou-Yi ^{[5
]}

Dhiaa, Aya Mohammed ^{[6
]}

Saadh, Mohamed J. ^{[7
]}

Pal, Yogendra ^{[8
]}

Thabit, Russul ^{[9
]}

Adhab, Ayat Hussein ^{[10
]}

Alsaikhan, Fahad ^{[11
,12
]}

Narmani, Asghar ^{[13
]}

Farhood, Bagher ^{[14
]}

机构：

[1] Baghdad Coll Med Sci, Dept Pharm, Baghdad, Iraq

[2] JSS Acad Higher Educ & Res, JSS Coll Pharm, Dept Pharm Practice, Nilgiris 643001, India

[3] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India

[4] Delhi Pharmaceut Sci & Res Univ, Sch Pharmaceut Sci, Dept Pharmacognosy & Phytochemistry, New Delhi 110017, India

[5] Chia Nan Univ Pharm & Sci, Dept Pharm, Tainan 71710, Taiwan

[6] Al Noor Univ Coll, Dept Pharm, Nineveh, Iraq

[7] Middle East Univ, Fac Pharm, Amman 11831, Jordan

[8] CT Coll Pharm, Dept Pharmaceut Chem, Jalandhar 144020, Punjab, India

[9] Al Farahidi Univ, Med Tech Coll, Baghdad, Iraq

[10] Al Zahrawi Univ Coll, Dept Pharm, Karbala, Iraq

[11] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Alkharj, Saudi Arabia

[12] Ibn Sina Natl Coll Med Studies, Sch Pharm, Jeddah, Saudi Arabia

[13] Univ Tehran, Fac New Sci & Technol, Dept Life Sci Engn, Tehran, Iran

[14] Kashan Univ Med Sci, Fac Paramed Sci, Dept Med Phys & Radiol, Kashan, Iran

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 264卷

关键词：

Chitosan nanofiber; Scaffolds; Physicochemical properties; Biological properties; Preparation; Bioactive delivery; Regenerative medicine; CORE-SHELL NANOFIBERS; COMPOSITE SCAFFOLDS; CONTROLLED-RELEASE; DRUG-DELIVERY; G4; DENDRIMER; PAMAM G4; IN-VITRO; TISSUE; NANOPARTICLES; FABRICATION;

D O I：

10.1016/j.ijbiomac.2024.130683

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nowadays, there is a wide range of deficiencies in treatment of diseases. These limitations are correlated with the inefficient ability of current modalities in the prognosis, diagnosis, and treatment of diseases. Therefore, there is a fundamental need for the development of novel approaches to overcome the mentioned restrictions. Chitosan (CS) nanoparticles, with remarkable physicochemical and mechanical properties, are FDA -approved biomaterials with potential biomedical aspects, like serum stability, biocompatibility, biodegradability, mucoadhesivity, nonimmunogenicity, anti-inflammatory, desirable pharmacokinetics and pharmacodynamics, etc. CS -based materials are mentioned as ideal bioactive materials for fabricating nanofibrous scaffolds. Sustained and controlled drug release and in situ gelation are other potential advantages of these scaffolds. This review highlights the latest advances in the fabrication of innovative CS -based nanofibrous scaffolds as potential bioactive materials in regenerative medicine and drug delivery systems, with an outlook on their future applications.

引用

页数：15

共 182 条

[1] Fabrication of carboxymethyl chitosan/poly(ε-caprolactone)/doxorubicin/nickel ferrite core-shell fibers for controlled release of doxorubicin against breast cancer [J].