Armored probiotics for oral delivery

被引：0

作者：

Yang, Xinyuan ^{[1
,2
]}

Wang, Chong ^{[1
,2
]}

Wang, Qiao ^{[1
,2
]}

Zhang, Zhuohao ^{[1
,2
]}

Nie, Weimin ^{[3
]}

Shang, Luoran ^{[1
,2
]}

机构：

[1] Fudan Univ, Zhongshan Xuhui Hosp, Shanghai, Peoples R China

[2] Fudan Univ, Inst Biomed Sci, Shanghai Key Lab Med Epigenet, Int Colab Med Epigenet & Metab,Minist Sci & Techno, Shanghai, Peoples R China

[3] Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery, Shanghai, Peoples R China

来源：

SMART MEDICINE | 2023年 / 2卷 / 04期

基金：

中国国家自然科学基金;

关键词：

encapsulation; functional biomaterials; gastrointestinal environment; oral delivery; probiotics; surface coating; INTERNATIONAL SCIENTIFIC ASSOCIATION; GUT MICROBIOTA; LACTOBACILLUS-PLANTARUM; CONSENSUS STATEMENT; ESCHERICHIA-COLI; BACTERIA; ALGINATE; PREBIOTICS; HOST; EXPRESSION;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

As a kind of intestinal flora regulator, probiotics show great potential in the treatment of many diseases. However, orally delivered probiotics are often vulnerable to unfriendly gastrointestinal environments, resulting in a low survival rate and decreased therapeutic efficacy. Decorating or encapsulating probiotics with functional biomaterials has become a facile yet useful strategy, and probiotics can be given different functions by wearing different armors. This review systematically discusses the challenges faced by oral probiotics and the research progress of armored probiotics delivery systems. We focus on how various functional armors help probiotics overcome different obstacles and achieve efficient delivery. We also introduce the applications of armor probiotics in disease treatment and analyze the future trends of developing advanced probiotics-based therapies. In this review, we systematically discuss the challenges faced by oral probiotics and the research progress of armored probiotics delivery systems. We focus on how various functional armors help probiotics overcome different obstacles and achieve efficient delivery. We also introduce the applications of armor probiotics in disease treatment and analyze the future trends of developing advanced probiotics-based therapies. image

引用

页数：18

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