Advancing in vivo reprogramming with synthetic biology

被引：3
作者：
Islam, Farhana [1 ]
Lewis, Mitchell R. [1 ]
Craig, James [1 ]
Leyendecker, Peyton M. [1 ]
Deans, Tara L. [1 ]
机构：
[1] Univ Utah, Dept Biomed Engn, Salt Lake City, UT 84112 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2024年 / 87卷
基金：
美国国家卫生研究院;
关键词：
CAR-T-CELLS; RNA; TRANSCRIPTION; SWITCH; PSEUDOURIDINE; EXPRESSION; CIRCUITS; PROTEINS; DELIVERY; FUTURE;
D O I：
10.1016/j.copbio.2024.103109
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Reprogramming cells will play a fundamental role in shaping the future of cell therapies by developing new strategies to engineer cells for improved performance and higher-order physiological functions. Approaches in synthetic biology harness cells' natural ability to sense diverse signals, integrate environmental inputs to make decisions, and execute complex behaviors based on the health of the organism or tissue. In this review, we highlight strategies in synthetic biology to reprogram cells, and discuss how recent approaches in the delivery of modified mRNA have created new opportunities to alter cell function in vivo. Finally, we discuss how combining concepts from synthetic biology and the delivery of mRNA in vivo could provide a platform for innovation to advance in vivo cellular reprogramming.
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页数：9
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