Advancing in vivo reprogramming with synthetic biology

被引：2
作者：
Islam, Farhana [1 ]
Lewis, Mitchell R. [1 ]
Craig, James [1 ]
Leyendecker, Peyton M. [1 ]
Deans, Tara L. [1 ]
机构：
[1] Univ Utah, Dept Biomed Engn, Salt Lake City, UT 84112 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2024年 / 87卷
基金：
美国国家卫生研究院;
关键词：
CAR-T-CELLS; RNA; TRANSCRIPTION; SWITCH; PSEUDOURIDINE; EXPRESSION; CIRCUITS; PROTEINS; DELIVERY; FUTURE;
D O I：
10.1016/j.copbio.2024.103109
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Reprogramming cells will play a fundamental role in shaping the future of cell therapies by developing new strategies to engineer cells for improved performance and higher-order physiological functions. Approaches in synthetic biology harness cells' natural ability to sense diverse signals, integrate environmental inputs to make decisions, and execute complex behaviors based on the health of the organism or tissue. In this review, we highlight strategies in synthetic biology to reprogram cells, and discuss how recent approaches in the delivery of modified mRNA have created new opportunities to alter cell function in vivo. Finally, we discuss how combining concepts from synthetic biology and the delivery of mRNA in vivo could provide a platform for innovation to advance in vivo cellular reprogramming.
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页数：9
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  • [1] Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation
    Anderson, Bart R.
    Muramatsu, Hiromi
    Nallagatla, Subba R.
    Bevilacqua, Philip C.
    Sansing, Lauren H.
    Weissman, Drew
    Kariko, Katalin
    [J]. NUCLEIC ACIDS RESEARCH, 2010, 38 (17) : 5884 - 5892
  • [2] From gene switches to mammalian designer cells: present and future prospects
    Auslaender, Simon
    Fussenegger, Martin
    [J]. TRENDS IN BIOTECHNOLOGY, 2013, 31 (03) : 155 - 168
  • [3] CAR T therapy beyond cancer: the evolution of a living drug
    Baker, Daniel J.
    Arany, Zoltan
    Baur, Joseph A.
    Epstein, Jonathan A.
    June, Carl H.
    [J]. NATURE, 2023, 619 (7971) : 707 - 715
  • [4] Self-amplifying RNA vaccines for infectious diseases
    Bloom, Kristie
    van den Berg, Fiona
    Arbuthnot, Patrick
    [J]. GENE THERAPY, 2021, 28 (3-4) : 117 - 129
  • [5] In vivo hematopoietic stem cell modification by mRNA delivery
    Breda, Laura
    Papp, Tyler E.
    Triebwasser, Michael P.
    Yadegari, Amir
    Fedorky, Megan T.
    Tanaka, Naoto
    Abdulmalik, Osheiza
    Pavani, Giulia
    Wang, Yongping
    Grupp, Stephan A.
    Chou, Stella T.
    Ni, Houping
    Mui, Barbara L.
    Tam, Ying K.
    Weissman, Drew
    Rivella, Stefano
    Parhiz, Hamideh
    [J]. SCIENCE, 2023, 381 (6656) : 436 - 443
  • [6] High-throughput enrichment and isolation of megakaryocyte progenitor cells from the mouse bone marrow
    Bush, Lucas M.
    Healy, Connor P.
    Marvin, James E.
    Deans, Tara L.
    [J]. SCIENTIFIC REPORTS, 2021, 11 (01)
  • [7] Biological Cells as Therapeutic Delivery Vehicles
    Bush, Lucas M.
    Healy, Connor P.
    Javdan, Shwan B.
    Emmons, Jonathan C.
    Deans, Tara L.
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2021, 42 (02) : 106 - 118
  • [8] The sound of silence: Transgene silencing in mammalian cell engineering
    Cabrera, Alan
    Edelstein, Hailey I.
    Glykofrydis, Fokion
    Love, Kasey S.
    Palacios, Sebastian
    Tycko, Josh
    Zhang, Meng
    Lensch, Sarah
    Shields, Cara E.
    Livingston, Mark
    Weiss, Ron
    Zhao, Huimin
    Haynes, Karmella A.
    Morsut, Leonardo
    Chen, Yvonne Y.
    Khalil, Ahmad S.
    Wong, Wilson W.
    Collins, James J.
    Rosser, Susan J.
    Polizzi, Karen
    Elowitz, Michael B.
    Fussenegger, Martin
    Hilton, Isaac B.
    Leonard, Joshua N.
    Bintu, Lacramioara
    Galloway, Kate E.
    Deans, Tara L.
    [J]. CELL SYSTEMS, 2022, 13 (12) : 950 - 973
  • [9] Transcription-dependent silencing of inducible convergent transgenes in transgenic mice
    Calero-Nieto, Fernando J.
    Bert, Andrew G.
    Cockerill, Peter N.
    [J]. EPIGENETICS & CHROMATIN, 2010, 3
  • [10] mRNA vaccines for infectious diseases: principles, delivery and clinical translation
    Chaudhary, Namit
    Weissman, Drew
    Whitehead, Kathryn A.
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2021, 20 (11) : 817 - 838
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