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Tissue-specific features of innate lymphoid cells in antiviral defense
被引:7
作者:
Piersma, Sytse J.
[1
,2
]
机构:
[1] Washington Univ, Sch Med, Dept Med, Div Rheumatol, St. Louis, MO 63110 USA
[2] Washington Univ, Siteman Canc Ctr, Sch Med, St Louis, MO 63110 USA
关键词:
NK cell;
innate lymphoid cell;
tissue microenvironment;
virus infection;
anti-viral immunity;
NATURAL-KILLER-CELLS;
ROR-GAMMA-T;
MURINE CYTOMEGALOVIRUS-INFECTION;
TRANSCRIPTION FACTOR GATA3;
CHEMOKINE RECEPTOR CXCR6;
CHRONIC HEPATITIS-B;
NK-CELLS;
VIRUS-INFECTION;
VIRAL-INFECTION;
DEPENDENT EXPANSION;
D O I:
10.1038/s41423-024-01161-x
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Innate lymphocytes (ILCs) rapidly respond to and protect against invading pathogens and cancer. ILCs include natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells and include type I, type II, and type III immune cells. While NK cells have been well recognized for their role in antiviral immunity, other ILC subtypes are emerging as players in antiviral defense. Each ILC subset has specialized functions that uniquely impact the antiviral immunity and health of the host depending on the tissue microenvironment. This review focuses on the specialized functions of each ILC subtype and their roles in antiviral immune responses across tissues. Several viruses within infection-prone tissues will be highlighted to provide an overview of the extent of the ILC immunity within tissues and emphasize common versus virus-specific responses.
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页码:1036 / 1050
页数:15
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