Intranasal drug delivery: The interaction between nanoparticles and the nose-to-brain pathway

被引：55

作者：

Chen, Yaoxing ^{[1
]}

Zhang, Chenyun ^{[1
]}

Huang, Yukun ^{[1
]}

Ma, Yuxiao ^{[1
]}

Song, Qingxiang ^{[1
]}

Chen, Hongzhuan ^{[2
]}

Jiang, Gan ^{[1
]}

Gao, Xiaoling ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Univ Collaborat Innovat Ctr Translat Med, Dept Pharmacol & Chem Biol, State Key Lab Syst Med Canc,Sch Med, 280 South Chongqing Rd, Shanghai 200025, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Interdisciplinary Integrat Biomed Res, 1200 Cailun Rd, Shanghai 201210, Peoples R China

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2024年 / 207卷

基金：

中国国家自然科学基金;

关键词：

Intranasal drug delivery; Target drug delivery; Nose-to-brain pathway; Biomimetic drug delivery systems; Synthesized drug delivery systems; Neurodegenerative diseases; NANOSTRUCTURED LIPID CARRIERS; CENTRAL-NERVOUS-SYSTEM; EPITHELIAL BARRIER; PLGA NANOPARTICLES; PHYSICOCHEMICAL PROPERTIES; POLYMERIC NANOPARTICLES; EXTRACELLULAR VESICLES; CHITOSAN NANOPARTICLES; OLFACTORY EPITHELIUM; ALZHEIMERS-DISEASE;

D O I：

10.1016/j.addr.2024.115196

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intranasal delivery provides a direct and non-invasive method for drugs to reach the central nervous system. Nanoparticles play a crucial role as carriers in augmenting the efficacy of brain delivery. However, the interaction between nanoparticles and the nose -to -brain pathway and how the various biopharmaceutical factors affect brain delivery efficacy remains unclear. In this review, we comprehensively summarized the anatomical and physiological characteristics of the nose -to -brain pathway and the obstacles that hinder brain delivery. We then outlined the interaction between nanoparticles and this pathway and reviewed the biomedical applications of various nanoparticulate drug delivery systems for nose -to -brain drug delivery. This review aims at inspiring innovative approaches for enhancing the effectiveness of nose -to -brain drug delivery in the treatment of different brain disorders.

引用

页数：18

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