FSP1-mediated ferroptosis in cancer: from mechanisms to therapeutic applications

被引：18

作者：

Gao, Ran ^{[1
,2
]}

Wang, Jinge ^{[3
]}

Huang, Jingjing ^{[1
,2
]}

Wang, Tong ^{[1
,2
]}

Guo, Lingfeng ^{[1
,2
]}

Liu, Wenlu ^{[1
,2
]}

Guan, Jialu ^{[1
,2
]}

Liang, Desen ^{[1
,2
]}

Meng, Qinghui ^{[1
,2
]}

Pan, Huayang ^{[1
,2
]}

机构：

[1] Harbin Med Univ, Key Lab Hepatosplen Surg, Minist Educ, Affiliated Hosp 1, Harbin, Peoples R China

[2] Harbin Med Univ, Dept Gen Surg, Affiliated Hosp 1, Harbin, Peoples R China

[3] Harbin Med Univ, Sch Publ Hlth, Harbin, Peoples R China

来源：

APOPTOSIS | 2024年 / 29卷 / 7-8期

基金：

中国国家自然科学基金;

关键词：

Ferroptosis suppressor protein 1; Ferroptosis; Antioxidant systems; Cancer therapies; Lipid peroxides; CELL LUNG-CANCER; IONIZING-RADIATION; OXIDATIVE STRESS; IRON; MITOCHONDRIAL; UBIQUINONE; PROTEIN; DEATH; ESCRT; FSP1;

D O I：

10.1007/s10495-024-01966-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ferroptosis is a new discovered regulated cell death triggered by the ferrous ion (Fe2+)-dependent accumulation of lipid peroxides associated with cancer and many other diseases. The mechanism of ferroptosis includes oxidation systems (such as enzymatic oxidation and free radical oxidation) and antioxidant systems (such as GSH/GPX4, CoQ10/FSP1, BH4/GCH1 and VKORC1L1/VK). Among them, ferroptosis suppressor protein 1 (FSP1), as a crucial regulatory factor in the antioxidant system, has shown a crucial role in ferroptosis. FSP1 has been well validated to ferroptosis in three ways, and a variety of intracellular factors and drug molecules can alleviate ferroptosis via FSP1, which has been demonstrated to alter the sensitivity and effectiveness of cancer therapies, including chemotherapy, radiotherapy, targeted therapy and immunotherapy. This review aims to provide important frameworks that, bring the regulation of FSP1 mediated ferroptosis into cancer therapies on the basis of existing studies.

引用

页码：1019 / 1037

页数：19

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