Osteoimmunology of Fracture Healing

被引：9

作者：

Molitoris, Kristin Happ ^{[1
]}

Huang, Mingjian ^{[1
]}

Baht, Gurpreet Singh ^{[1
]}

机构：

[1] Duke Univ, Duke Mol Physiol Inst, Dept Orthopaed Surg, 300 North Duke St, Durham, NC 27701 USA

来源：

CURRENT OSTEOPOROSIS REPORTS | 2024年 / 22卷 / 03期

关键词：

Bone fracture; Fracture callus; Immune cells; Inflammation; Hematopoietic cells; T-CELLS; B-CELL; OSTEOCLAST DIFFERENTIATION; PROINFLAMMATORY CYTOKINES; BONE REGENERATION; DENDRITIC CELLS; IN-VITRO; MACROPHAGES; INFLAMMATION; REPAIR;

D O I：

10.1007/s11914-024-00869-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of Review The purpose of this review is to summarize what is known in the literature about the role inflammation plays during bone fracture healing. Bone fracture healing progresses through four distinct yet overlapping phases: formation of the hematoma, development of the cartilaginous callus, development of the bony callus, and finally remodeling of the fracture callus. Throughout this process, inflammation plays a critical role in robust bone fracture healing.Recent Findings At the onset of injury, vessel and matrix disruption lead to the generation of an inflammatory response: inflammatory cells are recruited to the injury site where they differentiate, activate, and/or polarize to secrete cytokines for the purposes of cell signaling and cell recruitment. This process is altered by age and by sex.Summary Bone fracture healing is heavily influenced by the presence of inflammatory cells and cytokines within the healing tissue.

引用

页码：330 / 339

页数：10

共 97 条

[1] Role of Fas and Treg Cells in Fracture Healing as Characterized in the Fas- Deficient ( lpr) Mouse Model of Lupus [J].

Al-Sebaei, Maisa O. ;

Daukss, Dana M. ;

Belkina, Anna C. ;

Kakar, Sanjeev ;

Wigner, Nathan A. ;

Cusher, Daniel ;

Graves, Dana ;

Einhorn, Thomas ;

Morgan, Elise ;

Gerstenfeld, Louis C. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2014, 29 (06) :1478-1491

[2] Osteal Macrophages Promote In Vivo Intramembranous Bone Healing in a Mouse Tibial Injury Model [J].

Alexander, Kylie A. ;

Chang, Ming K. ;

Maylin, Erin R. ;

Kohler, Thomas ;

Mueller, Ralph ;

Wu, Andy C. ;

Van Rooijen, Nico ;

Sweet, Matthew J. ;

Hume, David A. ;

Raggatt, Liza J. ;

Pettit, Allison R. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2011, 26 (07) :1517-1532

[3]

Amarasekara DS, 2018, IMMUNE NETW, V18

[4] Aged skeletal stem cells generate an inflammatory degenerative niche [J].

Ambrosi, Thomas H. ;

Marecic, Owen ;

McArdle, Adrian ;

Sinha, Rahul ;

Gulati, Gunsagar S. ;

Tong, Xinming ;

Wang, Yuting ;

Steininger, Holly M. ;

Hoover, Malachia Y. ;

Koepke, Lauren S. ;

Murphy, Matthew P. ;

Sokol, Jan ;

Seo, Eun Young ;

Tevlin, Ruth ;

Lopez, Michael ;

Brewer, Rachel E. ;

Mascharak, Shamik ;

Lu, Laura ;

Ajanaku, Oyinkansola ;

Conley, Stephanie D. ;

Seita, Jun ;

Morri, Maurizio ;

Neff, Norma F. ;

Sahoo, Debashis ;

Yang, Fan ;

Weissman, Irving L. ;

Longaker, Michael T. ;

Chan, Charles K. F. .

NATURE, 2021, 597 (7875) :256-+

[5] Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration [J].

Andrew, Tom W. ;

Koepke, Lauren S. ;

Wang, Yuting ;

Lopez, Michael ;

Steininger, Holly ;

Struck, Danielle ;

Boyko, Tatiana ;

Ambrosi, Thomas H. ;

Tong, Xinming ;

Sun, Yuxi ;

Gulati, Gunsagar S. ;

Murphy, Matthew P. ;

Marecic, Owen ;

Telvin, Ruth ;

Schallmoser, Katharina ;

Strunk, Dirk ;

Seita, Jun ;

Goodman, Stuart B. ;

Yang, Fan ;

Longaker, Michael T. ;

Yang, George P. ;

Chan, Charles K. F. .

NATURE COMMUNICATIONS, 2022, 13 (01)

[6] T cells heal bone fractures with help from the gut microbiome [J].

Aurora, Rajeev ;

Silva, Matthew J. .

JOURNAL OF CLINICAL INVESTIGATION, 2023, 133 (08)

[7] Single-cell RNAseq provides insight into altered immune cell populations in human fracture nonunions [J].

Avin, Keith G. ;

Dominguez, James M. ;

Chen, Neal X. ;

Hato, Takashi ;

Myslinski, Jered J. ;

Gao, Hongyu ;

Liu, Yunlong ;

McKinley, Todd O. ;

Brown, Krista M. ;

Moe, Sharon M. ;

Natoli, Roman M. .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2023, 41 (05) :1060-1069

[8] Cellular biology of fracture healing [J].

Bahney, Chelsea S. ;

Zondervan, Robert L. ;

Allison, Patrick ;

Theologis, Alekos ;

Ashley, Jason W. ;

Ahn, Jaimo ;

Miclau, Theodore ;

Marcucio, Ralph S. ;

Hankenson, Kurt D. .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2019, 37 (01) :35-50

[9] The Role of the Immune Cells in Fracture Healing [J].

Baht, Gurpreet S. ;

Vi, Linda ;

Alman, Benjamin A. .

CURRENT OSTEOPOROSIS REPORTS, 2018, 16 (02) :138-145

[10] Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin [J].

Baht, Gurpreet S. ;

Silkstone, David ;

Vi, Linda ;

Nadesan, Puviindran ;

Amani, Yasha ;

Whetstone, Heather ;

Wei, Qingxia ;

Alman, Benjamin A. .

NATURE COMMUNICATIONS, 2015, 6

← 1 2 3 4 5 6 7 8 9 10 →