Targeting cardiomyocyte cell cycle regulation in heart failure

被引:5
作者
Zhu, Chaonan [1 ,2 ]
Yuan, Ting [1 ,2 ,3 ,4 ]
Krishnan, Jaya [1 ,2 ,3 ,4 ]
机构
[1] Goethe Univ Hosp, Dept Med 3, Cardiol Angiol Nephrol, D-60590 Frankfurt, Germany
[2] Goethe Univ, Inst Cardiovasc Regenerat, D-60590 Frankfurt, Germany
[3] German Ctr Cardiovasc Res, Partner Site Rhein Main, D-60590 Frankfurt, Germany
[4] Goethe Univ Hosp, Cardiopulm Inst, D-60590 Frankfurt, Germany
关键词
Cell cycle; Cardiomyocyte proliferation; Heart failure; CARDIAC EXTRACELLULAR-MATRIX; MYOCARDIAL-INFARCTION; MAMMALIAN HEART; CDK INHIBITORS; HIPPO PATHWAY; DNA-SYNTHESIS; DIFFERENTIATED CARDIOMYOCYTES; HYPERTROPHIC CARDIOMYOPATHY; BINUCLEATED CARDIOMYOCYTES; ADULT CARDIOMYOCYTES;
D O I
10.1007/s00395-024-01049-x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Heart failure continues to be a significant global health concern, causing substantial morbidity and mortality. The limited ability of the adult heart to regenerate has posed challenges in finding effective treatments for cardiac pathologies. While various medications and surgical interventions have been used to improve cardiac function, they are not able to address the extensive loss of functioning cardiomyocytes that occurs during cardiac injury. As a result, there is growing interest in understanding how the cell cycle is regulated and exploring the potential for stimulating cardiomyocyte proliferation as a means of promoting heart regeneration. This review aims to provide an overview of current knowledge on cell cycle regulation and mechanisms underlying cardiomyocyte proliferation in cases of heart failure, while also highlighting established and novel therapeutic strategies targeting this area for treatment purposes.
引用
收藏
页码:349 / 369
页数:21
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