Synthesis, Crystal Structure and Biological Activity of N-(tert-butyl)-N'-(2-(4-chlorophenyl)acetyl)-5-methyl-1,2,3-thiadiazole-4-carbohydrazide

被引：0

作者：

王盾 ^{[1
,2
]}

毛武涛 ^{[2
]}

范志金 ^{[2
]}

李娟娟 ^{[1
]}

黄云 ^{[1
]}

宋海斌 ^{[2
]}

范谦 ^{[3
]}

Tatiana A. Kalinina ^{[4
]}

Glukhareva Tatiana ^{[4
]}

Morzherin Yury Yur'evich ^{[4
]}

Belskaya N. Pavlovna ^{[4
]}

Bakulev V. Alekseevich ^{[4
]}

机构：

[1] Department of Plant Pathology,Sichuan Agricultural University

[2] State Key Laboratory of Elemento-organic Chemistry,Nankai University

[3] Sichuan Functional Heterocyclic Compounds Engineering Technology Research Center,Lier Chemicals Co.,Ltd.

[4] The Ural Federal University Named after the First President of Russia B. N. Yeltsin

来源：

结构化学 | 2013年 / 32卷 / 05期

关键词：

X-ray diffraction; crystal structure; synthesis; 3-thiadiazole; biological activity;

D O I：

暂无

中图分类号：

O626 [杂环化合物];

学科分类号：

070303 ; 081704 ;

摘要：

The title compound N-(tert-butyl)-N’-(2-(4-chlorophenyl)acetyl)-5-methyl-1,2,3-thiadiazole-4-carbohydrazide (C16H19ClN4NaO2S, Mr = 366.86) has been synthesized, and its structure was characterized by IR, 1H NMR, H RMS and single-crystal X-ray diffraction. The crystal of the title compound belongs to triclinic, space group Pī with a = 8.464(2), b = 10.192(2), c = 11.757(2), α = 68.48(3), β = 76.31(3), γ = 80.86(3)°, Z = 2, V = 2024.6(10) 3, Dc = 1.333 g/cm3, μ = 0.339 mm-1, F(000) = 384, R = 0.0450 and wR (Ⅰ > 2σ(Ⅰ)) = 0.1234. X-ray analysis indicates one N-H…N intermolecular hydrogen bond and no π-π stacking interactions are observed in this crystal structure. The preliminary biological test shows that the title compound has fungicidal activity and antivirus activities against tobacco mosaic virus.

引用

页码：673 / 678

页数：6

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