Synthesis,Crystal Structure and Biological Activity of 1-(4-(4-Ethoxybenzyl)piperazin-1-yl)-2-(2-methylphenoxy)ethanone

被引：0

作者：

李小凤 ^{[1
]}

陈晓宏 ^{[1
]}

仲琰 ^{[2
]}

许逸 ^{[1
]}

李萍 ^{[3
]}

吴斌 ^{[1
]}

机构：

[1] School of Pharmacy, Nanjing Medical University

[2] School of Chemistry and Chemical Engineering, Southeast University

[3] School of Basic Medical Sciences, Nanjing Medical University

来源：

结构化学 | 2017年 / 36卷 / 12期

关键词：

phenoxyacetamide; crystal structure; synthesis; anti-ischemic activity;

D O I：

暂无

中图分类号：

TQ460.1 [基础理论];

学科分类号：

1007 ;

摘要：

One novel phenoxyacetamide derivative(C22H28N2O3, Mr = 368.47) has been synthesized and determined by means of NMR spectroscopy, high resolution mass spectra and single-crystal X-ray diffraction. The single crystal belongs to the monoclinic system, space group Cc with a = 14.910（3）, b = 14.592（3）, c = 38.683（8） ?, β = 100.37（3）°, V = 8279（3） ?3, Z = 16, Dc = 1.183 g/cm3, F（000） = 3168, μ = 0.079 mm-1, Mo Kα radiation（λ = 0.71073 ?）, the final R = 0.0508 and wR = 0.0666 for 4120 observed reflections with I > 2σ（I）. There are four independent molecules in an asymmetric unit cell. The four symmetry-independent molecules have a variety of different conformations indicating considerable conformational freedom. The bioassay results indicated that the title compound displayed effective activities against glutamine-induced neurotoxicity in PC12 cells and significantly prolonged the survival time of mice subjected to acute cerebral ischemia.

引用

页码：2027 / 2032

页数：6

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