Synthesis,Crystal Structure and Anti-tumor Activity of Ethyl 3-(4-methoxyphenyl)-4-oxo-3,3a,4,6-tetrahydro-1H-furo[3,4-c]pyran-3a-carboxylate

被引：0

作者：

钟涵宇 ^{[1
]}

王甜甜 ^{[1
]}

张一凯 ^{[1
]}

陈焕 ^{[1
]}

吕志良 ^{[1
]}

张明峰 ^{[1
]}

耿冬平 ^{[1
]}

牛春娟 ^{[1
]}

李科 ^{[1
]}

机构：

[1] Department of Medicinal Chemistry,School of Pharmacy,Second Military Medical University

来源：

结构化学 | 2011年 / 30卷 / 12期

关键词：

3; 3a-dihydro-1H-furo[3; 4-c]pyran-4(6H)-one; synthesis; crystal structure; anti-tumor activity;

D O I：

暂无

中图分类号：

O621.3 [有机合成化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compound(ethyl 3-(4-methoxyphenyl)-4-oxo-3,3a,4,6-tetrahydro-1H-furo[3,4-c]pyran-3a-carboxylate) has been synthesized,and its crystal structure was characterized by X-ray single-crystal diffraction.The crystal belongs to monoclinic,space group P21/n,with a = 10.124(4),b = 11.754(4),c = 13.792(5) ,β = 111.533(3)o,V = 1526.6(10) 3,Z = 4,C17H19O6,Mr = 319.32,Dc = 1.389 g/cm3,F(000) = 676,λ(MoKα) = 0.71073 ,μ = 0.105 mm-1,R = 0.0660 and wR = 0.2027 for 2993 observed reflections(I > 2σ(I)).The compound shows potent anti-tumor activity in vitro.

引用

页码：1737 / 1741

页数：5

共 6 条

[1] Synthesis and Crystal Structure of (Z)-1- (3-Fluorobenzyl)-5-((3-fluorobenzylimino)(2-hydroxy-4-methoxyphenyl)methyl)pyridin-2(1H)-one
吕志良
王甜甜
张一凯
冯继禄
孙海玲
刘嘉
李科
[J]. 结构化学, 2009, 28 (12) : 1640 - 1644
[2] Synthesis and Crystal Structure of (Z)-Ethyl-4-(4-methoxy)benzylidene-2-(3,5-dimethoxypheny-tetrahydrofuran-3,3-dicarboxylate
王甜甜
吕志良
刘嘉
李科
[J]. 结构化学, 2009, 28 (07) : 803 - 806
[3] Synthesis, chiral resolution, and determination of novel furan lignan derivatives with potent anti-tumor activity[J] . Hai Ling Sun,Tian Tian Wang,Zhi Liang Lv,Ji Lu Feng,Dong Ping Geng,Yong Mei Li,Ke Li.Bioorganic & Medicinal Chemistry Letters . 2010 (6)
[4] Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs
Fuerst, Rita
Zupko, Istvan
Berenyi, Agnes
Ecker, Gerhard F.
Rinner, Uwe
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (24) : 6948 - 6951
[5] Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity[J] . Robert Lavieri,Sarah A. Scott,Jana A. Lewis,Paige E. Selvy,Michelle D. Armstrong,H. Alex Brown,Craig W. Lindsley.Bioorganic & Medicinal Chemistry Letters . 2009 (8)
[6] Anti-HIV activity of some synthetic lignanolides and intermediates
Sancho, R
Medarde, M
Sánchez-Palomino, S
Madrigal, BM
Alcamí, J
Muñoz, E
San Feliciano, A
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (17) : 4483 - 4486

← 1 →