Synthesis and Crystal Structure of (E)-Ethyl (9-bromo-5-oxo-4-phenyl-1,10b-dihydro-5H-pyrano3,4-cchromen-2-ylidene) Acetate

被引：0

作者：

王颖 ^{[1
]}

石德清 ^{[1
]}

机构：

[1] Key Laboratory of Pesticide and Chemical Biology of Ministry of Education,College of Chemistry,Central China Normal University

来源：

结构化学 | 2013年 / 32卷 / 04期

基金：

中央高校基本科研业务费专项资金资助;

关键词：

crystal structure; synthesis; 4+2 cycloaddition; dihydropyran-fused chromen-2-one;

D O I：

暂无

中图分类号：

O621.3 [有机合成化学];

学科分类号：

070303 ; 081704 ;

摘要：

The crystal structure of the title compound (C22H17BrO5 , Mr = 441.27) has been determined by single-crystal X-ray diffraction. The crystal is of orthorhombic system, space group Pna21 with a = 11.76(1), b = 14.58(1), c = 11.52(1), V = 1973.93 , Z = 4, Dc = 1.485 g/cm3 , F(000) = 896, μ(MoKα) = 2.113 mm-1 , the final R = 0.0394 and wR = 0.0809 for 3918 observed reflections (Ⅰ > 2 (Ⅰ)). The single-crystal X-ray diffraction data indicate that the C=C bond is in an E-configuration. The intramolecular C(10)-H(10B)···O(4) and intermolecular C(17)-H(17)···O(4) hydrogen bonds contribute to the stability of the structure.

引用

页码：521 / 524

页数：4

共 3 条

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[2] Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles[J] . A.M. Vijesh,Arun M. Isloor,Vivek Prabhu,Shaoib Ahmad,Shridhar Malladi.European Journal of Medicinal Chemistry . 2010 (11)
[3] Discovery of Potent Chromen-4-one Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) Using a Small-Molecule Library Approach .2 Hardcastle,I. R,Cockcroft,X,Curtin,N. J,El-Murr,M. D,Leahy,J. J. J,Stockley,M,Golding,B. T,Rigoreau,L,Richardson,C,Smith,G C. M,Griffin,R. J. J. Med. Chem . 2005

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