Effect of Berberine on the mRNA Expression of Nitric Oxide Synthase(NOS) in Rat Corpus Cavernosum

被引：0
|
作者：
谭艳
明章银
汤强
蒋兆键
胡本容
向继洲
机构：
[1] China 2Department of Pharmacology
[2] Shiyan 442000
[3] Wuhan 430030
[4] School of Basic Medical Sciences
[5] Huazhong University of Science and Technology
[6] Yunyang Medical College
[7] China
[8] Department of Pharmacology
[9] Tongji Medical College
来源：
华中科技大学学报(医学英德文版) | 2005年 / 02期
基金：
中国国家自然科学基金;
关键词：
berberine; nitric oxide synthase; nitric oxide; corpus cavernosum; erectile dysfunction;
D O I：
暂无
中图分类号：
R285 [中药药理学];
学科分类号：
1008 ;
摘要：
Summary: In order to further investigate the mechanisms of action of berberine (Ber), we assessed the effects of Ber on the mRNA expression of nitric oxide synthases (NOS) in rat corpus cavernosum. After incubation with Ber for 1 or 3 h respectively, the levels of NOS mRNA were examined by reverse transcription polymerase chain reaction (RT-PCR). Our results showed that there were iNOS and eNOS mRNA expressions in rat corpus cavernosum. Ber enhanced eNOS mRNA expression in rat penis, but exhibited no effect on the expression of iNOS mRNA (P>0.05). The present study indicated that the relaxation of Ber involved the NO-cGMP signal thansduction pathway. The enhancing effect of Ber on eNOS mRNA expression might associated with its relaxation of corpus cavernosum.
引用
收藏
页码：127 / 130
页数：4
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