Synthesis and Crystal Structure of (E)-2-phenyl-6,7dihydrobenzofuran-4(5H)-one O-cyanomethyl Oxime

被引：2
作者：
金蕾 [1 ]
方胡彪 [1 ]
曹成桥 [1 ]
黄年玉 [1 ]
邹坤 [1 ]
汪鋆植 [1 ,2 ]
机构：
[1] Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Sciences, China Three Gorges University
[2] Hubei Tujia Institute of Medicine
来源：
结构化学 | 2013年 / 32卷 / 09期
基金：
中国国家自然科学基金;
关键词：
X-ray diffraction; crystal structure; oxime ether; H+/K+-ATPase inhibitory activity; cytotoxic activity;
D O I：
暂无
中图分类号：
O782 [晶体生长工艺];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
A pair of E/Z-isomers of 2-phenyl-6,7-dihydrobenzofuran-4(5H)-one O-cyanomethyl oxime,C16H14N2O2,as potential drugs for treating peptic ulcer and other acid-related diseases have been synthesized and characterized by IR,MS and NMR spectra.Meanwhile,the crystal of IIIa was obtained and determined by X-ray single-crystal diffraction.Crystal data: monoclinic system,space group P21 /c,a = 8.423(8),b = 19.596(16),c = 8.770(8),β = 107.750(12)°,V = 1379(2)3,Z = 4,F(000) = 560,Dc = 1.283 g/cm3,μ = 0.086 mm 1,R = 0.0681 and wR = 0.2029 for 14472 independent reflections(Rint = 0.0782) and 2428 observed ones(I > 2σ(I)).
引用
收藏
页码：1334 / 1338
页数：5
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