Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy

被引：1
|
作者：
Xing-guo ZHANG1
机构：
来源：
JournalofZhejiangUniversity(ScienceB:AnInternationalBiomedicine&BiotechnologyJournal) | 2008年 / 06期
关键词：
Adefovir dipivoxil(ADV); Solid lipid nanoparticles(SLN); Octadecylamine-fluorescein isothiocynate(ODA-FITC); Hepatitis B virus(HBV);
D O I：
暂无
中图分类号：
R94 [药剂学];
学科分类号：
100602 ; 100702 ;
摘要：
Herein,solid lipid nanoparticles(SLN)were proposed as a new drug delivery system for adefovir dipivoxil(ADV). The octadecylamine-fluorescein isothiocynate(ODA-FITC)was synthesized and used as a fluorescence maker to be incorporated into SLN to investigate the time-dependent cellular uptake of SLN by HepG2.2.15.The SLN of monostearin with ODA-FITC or ADV were prepared by solvent diffusion method in an aqueous system.About 15 wt%drug entrapment efficiency(EE)and 3 wt% drug loading(DL)could be reached in SLN loading ADV.Comparing with free ADV,the inhibitory effects of ADV loaded in SLN on hepatitis B surface antigen(HBsAg),hepatitis B e antigen(HBeAg)and hepatitis B virus(HBV)DNA levels in vitro were significantly enhanced.
引用
收藏
页码：506 / 510
页数：5
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