Microwave Assistant Synthesis,Crystal Structure and Biological Activity of 1-(2-Fluorobenzyl)-3-methoxy-4-methyl-1H-1,2,4-triazol-5(4H)-one

被引：0

作者：

雷超 ^{[1
]}

申屠超 ^{[1
]}

机构：

[1] College of Biology and Environmental Engineering,Zhejiang Shuren University

来源：

结构化学 | 2015年 / 34卷 / 11期

关键词：

1,2,4-triazole; synthesis; crystal structure; fungicidal activities;

D O I：

暂无

中图分类号：

O626 [杂环化合物];

学科分类号：

070303 ; 081704 ;

摘要：

The title compound 1-(2-fluorobenzyl)-3-methoxy-4-methyl-1H-1,2,4-triazol-5(4H)-one(C11H12FN3O2) was synthesized,and its structure was confirmed by 1H NMR,IR,MS,elemental analysis and X-ray diffraction.It crystallizes in the monoclinic system,space group P1 with a=6.919(3),b=8.525(4),c=9.811(4) ?,α=84.22(2),β=71.028(19),γ=86.10(2)°,Dc=1.448 g/cm3,Z=2,V=544.2(4) ?3,F(000)=248,the final R=0.0379 and w R=0.0913 for 1709 observed reflections with I > 2σ(I).The preliminary biological test shows that the title compound shows weak inhibitory activities against Phytophthora infestans,Botrytis cinerea,Corynespora cassiicola,Rhizoctonia solani and Pythium ultimum.

引用

页码：1659 / 1664

页数：6

共 19 条

[1] Synthesis, Characterization and X-ray Structure of N-(4-bromobutanoyl-N'-(2-3-and 4-methylphenyl)thiourea[J]. Hamza M Abosadiya,Siti Aishah Hasbullah,Bohari M Yamin.结构化学. 2015(03)
[2] Synthesis,Crystal Structure and Antifungal Activity of 4-(5-((2,4-Dichlorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyridine
杨明艳
赵文
刘幸海
谭成侠
翁建全
[J]. 结构化学, 2015, 34 (02) : 203 - 207
[3] Microwave Assistant Synthesis and Dimeric Crystal Structure of 2-(((6-Chloropyridin-3-yl)-methyl)thio)-5-(pyridin-4-yl)-1,3,4-thiadiazole
孙召慧
翟志文
杨明艳
刘幸海
谭成侠
翁建全
[J]. 结构化学, 2014, 33 (12) : 1779 - 1783
[4] Construction and Photoluminescence Properties of Zn(Ⅱ)/Cd(Ⅱ) Complexes with 4-Amino-3,5-propyl-1,2,4-triazole Ligand
闫娟枝
朱苗力
高增强
董宇辉
[J]. 结构化学, 2014, 33 (08) : 1207 - 1214
[5] Synthesis, Crystal Structure and Biological Activity of a New 1,2,4-Triazole Derivative
童建颖
武宏科
孙娜波
刘幸海
[J]. 结构化学, 2013, 32 (04) : 607 - 611
[6] 新型含三唑啉酮的磺酰脲类化合物的合成、晶体结构及除草活性研究
潘里
陈有为
刘卓
李永红
李正名
[J]. 有机化学, 2013, 33 (03) : 542 - 550
[7] Synthesis and Crystal Structure of N-(1,3,4-Thiadiazol-2-yl)-1-[1-(6-chloropyridin-3-yl)methy]-5-methyl-1H-[1,2,3]triazol-4-carboxamide
陈小保
李克
石德清
[J]. 结构化学, 2008, (11) : 1389 - 1392
[8] Microwave Assisted Synthesis, Antifungal Activity, and DFT Study of Some Novel Triazolinone Derivatives[J] . Na-Bo Sun,Jian-Zhong Jin,Fang-Yue He,Lucia Lopalco.BioMed Research International . 2015
[9] Synthesis, crystal structure, herbicidal activities and 3D‐QSAR study of some novel 1,2,4‐triazolo[4,3‐ a]pyridine derivatives[J] . Xing‐Hai Liu,Xiao‐Yan Xu,Cheng‐Xia Tan,Jian‐Quan Weng,Jia‐Hua Xin,Jie Chen.Pest. Manag. Sci. . 2015 (2)
[10] Synthesis and bioactivities of novel 1,3,4-oxadiazole derivatives containing 1,2,3-thiadiazole moiety[J] . Guo-Xiang Sun,Ming-Yan Yang,Zhao-Hui Sun,Hong-Ke Wu,Xing-Hai Liu,Yun-Yang Wei.Phosphorus, Sulfur, and Silicon and the Related Elements . 2014 (12)

← 1 2 →