Synthesis,Crystal Structure and Bioactivity of a Pd(Ⅱ) Complex with Demethylcantharate and 2,2′-Bipyridine

被引：1

作者：

王鹏鹏 ^{[1
,2
]}

王彦君 ^{[2
]}

林秋月 ^{[1
,2
]}

沈玲丽 ^{[2
]}

赵玉玲 ^{[2
]}

机构：

[1] Zhejiang Key Laboratory for Reaction Chemistry on Solid Surfaces

[2] College of Chemical and Life Science,Zhejiang Normal University

来源：

结构化学 | 2012年 / 31卷 / 08期

关键词：

Pd(Ⅱ) complex; crystal structure; demethylcantharate; 2-bipyridine; interaction with DNA and BSA; antiproliferative activity;

D O I：

暂无

中图分类号：

O627.8 [第Ⅷ族元素有机化合物];

学科分类号：

070303 ; 081704 ;

摘要：

A novel crystal with the molecular formula [Pd(DCA)(bipy)]2 [Pd(bipy)Cl2 ]·6.75H2O was formed by PdCl2 with disodium demethylcantharate (Na2 (DCA),DCA2= 7-oxa-bicyclo[2.2.1]heptane-2,3-bicarboxylate) and 2,2-bipyidine (bipy) through the hydrothermal method.The complex was characterized by elemental analysis and infrared spectroscopy.The structure of the complex was determined by single-crystal X-ray diffraction,which is of triclinic system,space group P1 with a=13.6818(7),b=14.8426(8),c=15.0043(8),α=97.319(3),β=92.521(3),γ=105.776(2)°,V=2898.4(3) 3,Dc=1.545 g·cm-3,Z=1,F(000)=1420,S=0.852,the final R=0.0525 and wR=0.1777 for 13634 observer reflections (I>2σ(I)).The binding reaction of the complex with ct-DNA and bovine serum albumin (BSA) was studied by fluorescence spectroscopy.The results indicated that the complex binds to ct-DNA via the partial intercalation.The binding constant K A of the complex interaction with BSA was 3.98×10 5 L·mol-1 and one binding site would be formed.The antiproliferative activity of the complex against human hepatoma cells (SMMC7721) in vitro is much higher than that of Na 2 (DCA).

引用

页码：1175 / 1181

页数：7

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