Synthesis,Bioactivity and Crystal Structure Analysis of Novel Benzo[d]isothiazol-3(2H)-ones

被引：9

作者：

王向辉 ^{[1
,2
]}

林强 ^{[2
]}

尹学琼 ^{[3
]}

游诚航 ^{[3
]}

杨建新 ^{[3
]}

机构：

[1] Institute of Environmental Science and Engineering,Kunming University of Science and Technology

[2] Institute of Chemistry and Chemical Engineering,Hainan Normal University

[3] Hainan Provincial Fine Chemical Engineering Center,Department of Materials and Chemical Engineering,Hainan University

来源：

结构化学 | 2012年 / 31卷 / 08期

基金：

中国国家自然科学基金;

关键词：

benzo[d]isothiazol-3(2H)-one (BIT); crystal structure; antimicrobial activity;

D O I：

暂无

中图分类号：

O626.25 [间硫氮茂（噻唑）];

学科分类号：

070303 ; 081704 ;

摘要：

Two compounds,3-oxo-N-o-tolylbenzo[d]isothiazole-2(3H)-carboxamide (1) and N-(2-methoxyphenyl)-3-oxobenzo[d]isothiazole-2(3H)-carboxamide (2),were synthesized from the initial compound benzo[d]isothiazol-3(2H)-one (BIT) and characterized by 1 H NMR,IR and elemental analysis,respectively.The single crystals of compounds 1 and 2 were obtained and determined by X-ray diffraction analysis.The preliminary results of biological activity experiment show that some of the title compounds exhibited a favorable antimicrobial activity.

引用

页码：1170 / 1174

页数：5

共 50 条

[1] Synthesis, Bioactivity and Crystal Structure Analysis of Novel Benzo[d]isothiazol-3(2H)-ones
Wang Xiang-Hui
Lin Qiang
Yin Xue-Qiong
You Cheng-Hang
Yang Jian-Xin
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2012, 31 (08) : 1170 - 1174
[2] Crystal structure and antimycobacterial evaluation of 2-(cyclohexylmethyl)-7-nitro-5-(trifluoromethyl)benzo[d]isothiazol-3(2H)-one
Richter, Adrian
Goddard, Richard
Imming, Peter
Seidel, Ruediger W.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2023, 79 : 1194 - +
[3] Synthesis, Crystal Structure and Antimicrobial Activity of (E)-2-(2-(4,8,8-Trimethyldecahydro-1,4-methanoazulen-9-ylidene)ethyl)benzo[d]isothiazol-3(2H)-one
Lan Hong-Yun
Huo Shang-Chao
Huang Dao-Zhan
Lu Yu-zhou
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2020, 39 (08) : 1546 - 1552
[4] Synthesis, Bioactivity, and Crystal Structure Analysis of 2-(3-Oxobenzo[d]isothiazol-2(3H)-yl)ethyl Benzoates
王向辉
游诚航
林强
结构化学, 2013, 32 (08) : 1123 - 1130
[5] Synthesis, Bioactivity, and Crystal Structure Analysis of 2-(3-Oxobenzo[d]isothiazol-2(3H)-yl)ethyl Benzoates
Wang Xiang-Hui
You Cheng-Hang
Lin Qiang
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2013, 32 (08) : 1123 - 1130
[6] Synthesis, Bioactivity and Crystal Structure Analysis of 2-(Benzo[d]isothiazol-3-yloxy)-N-(3-cyano-1-(4-fluorophenyl)-1H-pyrazol-5-yl) Acetamide
Yu Peng
Li Xi
Hu Jun
Xu Yan-Hua
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2014, 33 (09) : 1375 - 1382
[7] Synthesis, Bioactivity and Crystal Structure Analysis of 2-(Benzo[d]isothiazol-3-yloxy)-N-(3-cyano-1-(4-fluorophenyl)-1H-pyrazol-5-yl) Acetamide
于鹏
李溪
胡俊
徐炎华
结构化学, 2014, 33 (09) : 1375 - 1382
[8] The reactivity of tetrahydropyrrolo[1,2-b]isothiazol-3(2H)-one 1,1-dioxides
Omelian, Taras V.
Dobrydnev, Alexey V.
Utchenko, Oleksandr Yu.
Ostapchuk, Eugeniy N.
Konovalova, Irina S.
Volovenko, Yulian M.
MONATSHEFTE FUR CHEMIE, 2020, 151 (11): : 1759 - 1772
[9] Synthesis, Bioactivity and Crystal Structure Analysis of N-(2-ethoxyphenyl)3-oxobenzo[d]isothiazole-2(3H)-carboxamide
Wang Xiang-Hui
Yang Jian-Xin
Lin Qiang
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2012, 31 (05) : 758 - 762
[10] A facile and simple synthesis of novel isoxazolyl benzo[f][1,4]oxazepin-3-(2H)-ones and their antimicrobial activity
Kakkerla, Ramu
Marri, Srinivas
Krishna, M. P. S. Murali
Rajam, M. V.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2018, 57 (06): : 823 - 829

← 1 2 3 4 5 →