THE EFFECT OF THYROIDECTOMY AND ANTITHYROID DRUGS UPON ANTIMONY POTASSIUM TARTRATE TOXICITY

<正> Diaminodiphenoxyalkanes have been reported recently to be effectivein experimental schistosomiasis (1-4) ; however its clinical result in thiscountry has been disappointing (5). For lack of a better drug for thetreatment of schistosomiasis japonica, antimony potassium tartrate (a.p.t.)is still mostly used. The only drawback is its high toxicity. It is there-fore necessary to find a way of decreasing its toxicity.Braun and others(6) studied antimony detoxication in 1946 and foundthat dimercaprol was effective in the treatment of antimony poisoning.Lee(7), Wang(8) and Chang's(9) studies on this subject have demonstratedthe following: 1. Cysteine in dosages of 500 mg per kg has a definite protec-tive action against a.p.t. in mice. 2. Methionine has the same, but lesseffective action. 3. Calcium chloride can facilitate the recovery of anisolated frog's heart inhibited by a.p.t.Liang et al(10), in a study of the effect of certain drugs upon a.p.t.toxicity, found that procaine, sodium acetate, sodium mercaptosuccinateand sodium aa'-dimercaptoadipate have a protective action against sub-acute a.p.t. toxicity. In the investigation made by Yu et al(11), a.p.t.when mixed with 0.1 per cent thiouracil showed a significant decreasein toxicity for twenty-four days. They proposed three possible explana-tions for the mechanism of this toxicity diminution: 1. The sulfhydrylgroup of the enol-form of thiouracil combines with antimony in a.p.t.directly in vivo. 2. Thiouracil may alter a.p.t. toxicity by its goitrogenous