Effects of lactulose on intestinal endotoxin and bacterial translocation in cirrhotic rats

被引:0
作者
张顺财
王唯
任卫英
戴茜
贺伯明
周康
机构
[1] Department of Gastroenterology
[2] Zhongshan Hospital
[3] Shanghai Medical University
[4] Shanghai
[5] China
[6] Institute of Materia Medica
[7] Chinese Academy of Science
[8] Shanghai
关键词
D O I
暂无
中图分类号
R575.2 [肝硬变];
学科分类号
摘要
Objective To investigate the effects of lactulose on intestinal bacterial overgrowth (IBO), bacterial translocation (BT), intestinal transit and permeability in cirrhotic rats. Methods BT in all animals was assessed by bacterial culture of mesenteric lymph node (MLN), liver and spleen, and IBO was assessed by a jejunal bacterial count of the specific organism. Intestinal permeability was determined by the 24-hour urinary 99mTc-diethylenetriamine pentaacetatic acid ( 99mTc-DTPA) excretion, and intestinal transit was determined by measuring the distribution of 51Cr in the intestine. Results BT and IBO were found in 48% and 80% of the cirrhotic rats, respectively, while not in the control rats. Cirrhotic rats with IBO had significantly higher levels of intestinal endotoxin higher rates of bacterial translocation, shorter intestinal transit time and higher intestinal permeability than those without IBO. It was also found that BT were closely associated with IBO and injury of the intestinal barrier. Compared with the placebo group, lactulose-treated rats had lower rates of BT and IBO, which were closely associated with increased intestinal transit and improved intestinal permeability by lactulose. Conclusions Our study indicate that endotoxin and bacterial translocation in cirrhotic rats may attribute to IBO and increased intestinal permeability. Lactulose that accelerates intestinal transit and improves intestinal permeability might be helpful in preventing intestinal bacterial and endotoxin translocation.
引用
收藏
页数:5
相关论文
共 50 条
  • [41] Effects of recombinant human growth hormone on intestinal translocation of bacteria and endotoxin in rats with obstructive jaundice
    Department of General Surgery ( Yang ZW
    Hepatobiliary & Pancreatic Diseases International, 2005, (03) : 445 - 449
  • [42] Effects of lactulose and lactitol on coliform bacteria and bacterial translocation in the caecum during 72-h starvation in rats
    Demirogullari, B
    Cirak, MY
    Poyraz, A
    Sonmez, K
    Kulah, C
    Turkyilmaz, Z
    Karabulut, R
    Yilmaz, Y
    Basaklar, AC
    Kale, N
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2003, 135 (03): : 249 - 255
  • [43] Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats
    Lorenzo-Zúñiga, V
    Bartolí, R
    Planas, R
    Hofmann, AF
    Viñado, B
    Hagey, LR
    Hernández, JM
    Mañé, J
    Alvarez, MA
    Ausina, V
    Gassull, MA
    HEPATOLOGY, 2003, 37 (03) : 551 - 557
  • [44] Effect of propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascites
    Pérez-Paramo, M
    Muñoz, J
    Albillos, A
    Freile, I
    Portero, F
    Santos, M
    Ortiz-Berrocal, J
    HEPATOLOGY, 2000, 31 (01) : 43 - 48
  • [45] INCREASED BACTERIAL TRANSLOCATION IN CIRRHOTIC RATS UNDERGOING HEMORRHAGIC-SHOCK
    HAMDANI, R
    YOUNG, S
    RUNYON, B
    GASTROENTEROLOGY, 1994, 106 (04) : A904 - A904
  • [46] Ileal mucosal oxidative damage and bacterial translocation in cirrhotic rats.
    Peralta, C
    Chiva, M
    Gomez, G
    Soriano, G
    Llovet, T
    Guarner, C
    Balanzo, J
    HEPATOLOGY, 1999, 30 (04) : 579A - 579A
  • [47] Bacterial Translocation and Intestinal Morphological Findings in Jaundiced Rats
    Pierpaolo Sileri
    Sergio Morini
    Giuseppe S. Sica
    Stefano Schena
    Cristiana Rastellini
    Achille L. Gaspari
    Enrico Benedetti
    Luca Cicalese
    Digestive Diseases and Sciences, 2002, 47 : 929 - 934
  • [48] Bacterial translocation and intestinal morphological findings in jaundiced rats
    Sileri, P
    Morini, S
    Sica, GS
    Schena, S
    Rastellini, C
    Gaspari, AL
    Benedetti, E
    Cicalese, L
    DIGESTIVE DISEASES AND SCIENCES, 2002, 47 (04) : 929 - 934
  • [49] INTESTINAL BACTERIAL TRANSLOCATION IN RATS WITH CIRRHOSIS IS RELATED TO INTESTINAL IMMUNE DYSFUNCTION
    Shi, H.
    Jiang, H.
    Li, L.
    JOURNAL OF HEPATOLOGY, 2016, 64 : S445 - S446
  • [50] Lactulose to prevent bacterial translocation in biliary obstruction
    Ozcelik, MF
    Pekmezci, S
    Altinli, E
    Eroglu, C
    Goksel, S
    Goksoy, E
    DIGESTIVE SURGERY, 1997, 14 (04) : 267 - 271