Successful second transplantation from haploidentical donor for graft failure following unrelated cord blood cell transplantation or mismatched related transplantation:2 cases report

<正> Cord blood transplantation (CBT) from unrelateddonors has increasingly been performedworldwide during the last decade.The immaturity oflymphocytes in cord blood permits HLA-mismatchingbetween donors and recipients and reduces theseverity of graft-versus-host disease (GVHD).However,the relatively small dose of the cord bloodnucleated cells is associated with a high frequencyof engraftment failure.But re-transplantation withstem cells from the original donor is impossible.Ninety percent of patients have a donor fromgenetically haploidentical family members;